About: Metody pro charakterizaci konjugátů radionuklid - ligand

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	At present, the importance of complexes, when the radionuclide was transported to tumor via antibody labeled by a and b emitters, increasingly grows in the targeted therapy of cancers. We were dealing with the study of the human immunoglobulin G (IgG) and anti-CD 20 conjugations with the bicyclic anhydride of the diethylentriamino-N,N,N,N,N-pentaacetate acid (cDTPAA) and labeling of prepared conjugates by 90Y (carrier-free) and 177Lu radionuclides. The HPLC - SEC method, the ultrafiltation and the gel was used for separationof the antibody - DTPA conjugate and free DTPA. The characterization of the bifunctional chelaton bond to antibody was carried out by FTIR spectroscopy. At present, the importance of complexes, when the radionuclide was transported to tumor via antibody labeled by a and b emitters, increasingly grows in the targeted therapy of cancers. We were dealing with the study of the human immunoglobulin G (IgG) and anti-CD 20 conjugations with the bicyclic anhydride of the diethylentriamino-N,N,N,N,N-pentaacetate acid (cDTPAA) and labeling of prepared conjugates by 90Y (carrier-free) and 177Lu radionuclides. The HPLC - SEC method, the ultrafiltation and the gel was used for separationof the antibody - DTPA conjugate and free DTPA. The characterization of the bifunctional chelaton bond to antibody was carried out by FTIR spectroscopy. (en) At present, the importance of complexes, when the radionuclide was transported to tumor via antibody labeled by a and b emitters, increasingly grows in the targeted therapy of cancers. We were dealing with the study of the human immunoglobulin G (IgG) and anti-CD 20 conjugations with the bicyclic anhydride of the diethylentriamino-N,N,N,N,N-pentaacetate acid (cDTPAA) and labeling of prepared conjugates by 90Y (carrier-free) and 177Lu radionuclides. The HPLC - SEC method, the ultrafiltation and the gel was used for separationof the antibody - DTPA conjugate and free DTPA. The characterization of the bifunctional chelaton bond to antibody was carried out by FTIR spectroscopy. (cs)
Title	Metody pro charakterizaci konjugátů radionuklid - ligand - protilátka Metody pro charakterizaci konjugátů radionuklid - ligand - protilátka (en) Metody pro charakterizaci konjugátů radionuklid - ligand - protilátka (cs)
skos:prefLabel	Metody pro charakterizaci konjugátů radionuklid - ligand - protilátka Metody pro charakterizaci konjugátů radionuklid - ligand - protilátka (en) Metody pro charakterizaci konjugátů radionuklid - ligand - protilátka (cs)
skos:notation	RIV/60461373:22340/05:00014550!RIV06-GA0-22340___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA104/03/0499), Z(MSM6046137307)
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Reková, Marie Křížová, Věra
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	529991
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/05:00014550
http://linked.open...riv/jazykVysledku	cze - čeština
http://linked.open.../riv/klicovaSlova	radionuklid; ligand; protilátka (en)
http://linked.open.../riv/klicoveSlovo	protilátka radionuklid ligand
http://linked.open...ontrolniKodProRIV	[A96DCC498A31]
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Technology of the preparations of radionuclides and their labelled compounds for applications in medicine and pharmacy with the use of reactor LVR-15
http://linked.open...UplatneniVysledku	2005
http://linked.open...iv/tvurceVysledku	Křížová, Věra Reková, Marie
http://linked.open...n/vavai/riv/zamer	Physico-chemical methods of analysis and characterization of chemical systems and biosystems
http://localhost/t...ganizacniJednotka	22340

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