| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Biolocalisation and photochemical properties of novel macrocyclic photosensitisers, guanidiniocarbonyl-substituted tetraphenylporphyrin (1) and sugar-substituted sapphyrin (2) were investigated by spectroscopic methods. Both photosensitisers absorb in far visible region and showed good tumour localisation. Photosensitiser 2 demonstrated significantly larger absolute and relative to normal tissue (T/N) amount in tumour (330 mug g(-1) wet tissue, T/N = 19.0) than photosensitiser 1 did (13 mug g(-1) wet tissue, T/N = 2.1). According to iodometric and uric acid assays, compound 1 produced large amount of O-1(2) (Phi(Delta) = 0.60-0.68), while compound 2 showed non-significant O-1(2) production (Phi(Delta) = 0.04). The electronic spectroscopic study confirms that only photosensitiser 1 is able to mediate photooxidation of model compounds (BSA, poly(Trp), Tyr, Trp, and GMP) after light irradiation. Pour photochemical activity of compound 2 was explained by its self-aggregation. Raman spectroscopic study ind
- Biolocalisation and photochemical properties of novel macrocyclic photosensitisers, guanidiniocarbonyl-substituted tetraphenylporphyrin (1) and sugar-substituted sapphyrin (2) were investigated by spectroscopic methods. Both photosensitisers absorb in far visible region and showed good tumour localisation. Photosensitiser 2 demonstrated significantly larger absolute and relative to normal tissue (T/N) amount in tumour (330 mug g(-1) wet tissue, T/N = 19.0) than photosensitiser 1 did (13 mug g(-1) wet tissue, T/N = 2.1). According to iodometric and uric acid assays, compound 1 produced large amount of O-1(2) (Phi(Delta) = 0.60-0.68), while compound 2 showed non-significant O-1(2) production (Phi(Delta) = 0.04). The electronic spectroscopic study confirms that only photosensitiser 1 is able to mediate photooxidation of model compounds (BSA, poly(Trp), Tyr, Trp, and GMP) after light irradiation. Pour photochemical activity of compound 2 was explained by its self-aggregation. Raman spectroscopic study ind (en)
- Biolokalizace a fotochemické vlastnosti nových makrocyklických fotosensitizérů, guanidiniokarbonyl-substituovaného tetrafenylporfyrinu (1) a cukrem-substituovaného safyrinu (2) byly zkoumány spektroskopickými metodami. Oba fotosensitizéry absorbují v daleké viditelné oblasti a vykazují dobrou lokalizaci v nádoru. Fotosensitizér 2 vykázal jednoznačně vyšší absolutní i relativní k normální tkáni (T/N) množství v nádoru (300 micro g g-1 mokré tkáně, T/N=2.1). Podle jodometrické zkoušky a zkoušky na kyselinu močovou produkovala látka 1 vyšší množství 1O2 (??=0.60-0.68), zatímco látka 2 nevykazovala významnou produkci 1O2 (??=0.04). Elektronická spektroskopická studie potvrdila, že pouze fotosensitizér 1 schopen zprostředkovat fotooxidaci modelových látek (BSA, poly(Trp), Tyr, Trp, a GMP) po ozáření světlem. Slabá fotochemická aktivita látky 2 byla vysvětlena jeho samoagregací. Ramanova spektroskopická studie ukázala, že monomerní fotosensitizér 2 účinně poškodil BSA a DNA z telecího brzlíku po světelné ex (cs)
|
| Title
| - Biolokalizace a fotochemické vlastnosti dvou makrocyklických fotosensitiserů: spektroskopické studium (cs)
- Biolocalisation and photochemical properties of two novel macrocyclic photosensitisers: a spectroscopic study
- Biolocalisation and photochemical properties of two novel macrocyclic photosensitisers: a spectroscopic study (en)
|
| skos:prefLabel
| - Biolokalizace a fotochemické vlastnosti dvou makrocyklických fotosensitiserů: spektroskopické studium (cs)
- Biolocalisation and photochemical properties of two novel macrocyclic photosensitisers: a spectroscopic study
- Biolocalisation and photochemical properties of two novel macrocyclic photosensitisers: a spectroscopic study (en)
|
| skos:notation
| - RIV/60461373:22340/04:00013203!RIV/2005/GA0/223405/N
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA203/02/0420), Z(MSM 223400008)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22340/04:00013203
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Novel macrocyclic photosensitisers;self-aggregation;biolocalisation in tumour;singlet oxygen;photodynamic damage;electronic spectroscopy;Raman spectroscopy (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Journal of Photochemistry and Photobiology B: Biology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Král, Vladimír
- Synytsya, Alla
- Volka, Karel
- Blechová, M.
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)