About: A discrete model of signal transmission in an epithelial layer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pattern formation and other processes (cancer, programmed cell death etc.) in epithelial layers heavily relies on cell communication by secreted ligands - growth factors. These, mostly extracellular, ligands activate or inhibit intracellular metabolic pathways that control secretion of the growth factors. The released growth factors can diffuse through the extracellular space and interact with receptors on a cell surface (autocrine and paracrine signaling). The resulting combination of ligands bound on receptors and their concentration determinates the cell development. This contribution is devoted to the mathematical analysis of a positive feedback in cell-cell interactions (ligand-receptor interaction complex formation activation of ligand release ligand transport ligand-receptor interaction). A mathematical model of the cell-cell signaling was proposed. The model is relevant to the physiology of epithelial layers and to a number of in-vitro experiments. The model analysis predicts exist Pattern formation and other processes (cancer, programmed cell death etc.) in epithelial layers heavily relies on cell communication by secreted ligands - growth factors. These, mostly extracellular, ligands activate or inhibit intracellular metabolic pathways that control secretion of the growth factors. The released growth factors can diffuse through the extracellular space and interact with receptors on a cell surface (autocrine and paracrine signaling). The resulting combination of ligands bound on receptors and their concentration determinates the cell development. This contribution is devoted to the mathematical analysis of a positive feedback in cell-cell interactions (ligand-receptor interaction complex formation activation of ligand release ligand transport ligand-receptor interaction). A mathematical model of the cell-cell signaling was proposed. The model is relevant to the physiology of epithelial layers and to a number of in-vitro experiments. The model analysis predicts exist (en)
Title	A discrete model of signal transmission in an epithelial layer A discrete model of signal transmission in an epithelial layer (en)
skos:prefLabel	A discrete model of signal transmission in an epithelial layer A discrete model of signal transmission in an epithelial layer (en)
skos:notation	RIV/60461373:22340/03:00007560!RIV/2004/MSM/223404/N
http://linked.open.../vavai/riv/strany	B6(2-10)
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 223400007)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Přibyl, Michal
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	596871
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/03:00007560
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	epithelial layer; cell communication; ligand; receptor; transport; signaling; pattern formation; mathematical modeling; stable pattern (en)
http://linked.open.../riv/klicoveSlovo	cell communication epithelial layer stable pattern mathematical modeling receptor transport signaling ligand pattern formation
http://linked.open...ontrolniKodProRIV	[8D24C42280DB]
http://linked.open...v/mistoKonaniAkce	Tatranské Matliare, Slovakia
http://linked.open...i/riv/mistoVydani	Bratislava
http://linked.open...i/riv/nazevZdroje	Proceedings of the 30th International Conference of Slovak Society of Chemical Engineering, Tatranské Matliare 26.- 30.5.2003, CD-ROM
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Přibyl, Michal Schvartsman, Stanislav
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2003-05-26 (xsd:date)
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223400007
number of pages	9 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Slovenská technická univerzita v Bratislave
https://schema.org/isbn	80-227-1889-0
http://localhost/t...ganizacniJednotka	22340

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