About: Radioactively labelled porphyrin derivatives

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Radioactive labelling guanidine-bearing tetraphenylporphyrin and Dy-texaphirin with selected radionuclides (166Ho and 90Y) is described. A basic characterisation of studied porphyrin and texaphyrin, including their behaviour in a wide range of pH values and data on holmium and yttrium complexation with these compounds was probed using UV-VIS absorption spectrometry. The labelling yield of these macrocyclic molecules depends on the pH of the reaction mixture, metal:ligand ratio and time of incubation. Optimal reaction conditions for formation of porphyrin and texaphyrin radioactive complexes were determined by thin layer chromatography with the detection of B- activity. The ability of porphyrin derivatives to bind anions was examined as well. Our eyperiments were focused on perrhenate ion (ReO4-) because radiopharmaceuticals labelled with isotopes 186Re and 188Re play an important role in therapy of numerous tumour diseases. The possibility of applying ReO4- anion directly for labelling purposes, witho Radioactive labelling guanidine-bearing tetraphenylporphyrin and Dy-texaphirin with selected radionuclides (166Ho and 90Y) is described. A basic characterisation of studied porphyrin and texaphyrin, including their behaviour in a wide range of pH values and data on holmium and yttrium complexation with these compounds was probed using UV-VIS absorption spectrometry. The labelling yield of these macrocyclic molecules depends on the pH of the reaction mixture, metal:ligand ratio and time of incubation. Optimal reaction conditions for formation of porphyrin and texaphyrin radioactive complexes were determined by thin layer chromatography with the detection of B- activity. The ability of porphyrin derivatives to bind anions was examined as well. Our eyperiments were focused on perrhenate ion (ReO4-) because radiopharmaceuticals labelled with isotopes 186Re and 188Re play an important role in therapy of numerous tumour diseases. The possibility of applying ReO4- anion directly for labelling purposes, witho (en)
Title	Radioactively labelled porphyrin derivatives Radioactively labelled porphyrin derivatives (en)
skos:prefLabel	Radioactively labelled porphyrin derivatives Radioactively labelled porphyrin derivatives (en)
skos:notation	RIV/60461373:22340/03:00007460!RIV/2004/MSM/223404/N
http://linked.open.../vavai/riv/strany	755-761
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 223400008)
http://linked.open...iv/cisloPeriodika	53
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Ernestová, Milena Pataridu, Radka Král, Vladimír Křížová, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	624496
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/03:00007460
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Holmium; Yttrium; Rhenium; Porphyrin; UV-VIS Spektrometry; Thin layer Chormatography (en)
http://linked.open.../riv/klicoveSlovo	Rhenium Porphyrin Yttrium Holmium Thin layer Chormatography UV-VIS Spektrometry
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[5932E1F8337D]
http://linked.open...i/riv/nazevZdroje	Czechoslovak Journal of Physics
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Král, Vladimír Křížová, Věra Konířová, Radka Ernestová, Milena
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223400008
issn	0011-4626
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	22340

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