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| rdf:type
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| Description
| - In recent years, interest in hop-derived constituents, especially for prenyl?avonoids has grown, as they have a wide range of biological properties including antioxidant, anticarcinogenic and antimicrobial activities. Two main hop prenyl?avonoids, xanthohumol and isoxanthohumol, and hop extract enriched in prenyl?avonoids, were tested for their antiproliferative activities on colon cancer cell lines, HT-29 and SW620, and a noncancerous cell line, IEC-6. It was con?rmed that both xanthohumol and isoxanthohumol inhibited cell proliferation, even at micromolar concentrations. For cell line HT-29, the IC50 was 1.2 +- 0.9 and 16.9 +- 0.9mýmol dm 3 for xanthohumol and isoxanthohumol, respectively. Similar values were obtained for SW620 cells (2.5 +- 0.2 and 37.3 +- 3.2mýmol dm-3). None of the pure prenyl?avonoids that were tested affected the proliferation of the noncancerous cell line, IEC-6. The effect of the hop extract containing xanthohumol was also tested for antiproliferative activities on the cancer cell lines, HT-29 (IC50= 3.1 +- 0.2mýmol dm-3 ) and SW620 (IC50= 1 +- 0.2mýmol dm-3), and on the cell line, IEC-6 (IC50= 65.5 +- 11.3mýmol dm-3). The results showed a similar trend to that for pure compounds, suggesting a possible future application of hop extracts in the pharmaceutical industry.
- In recent years, interest in hop-derived constituents, especially for prenyl?avonoids has grown, as they have a wide range of biological properties including antioxidant, anticarcinogenic and antimicrobial activities. Two main hop prenyl?avonoids, xanthohumol and isoxanthohumol, and hop extract enriched in prenyl?avonoids, were tested for their antiproliferative activities on colon cancer cell lines, HT-29 and SW620, and a noncancerous cell line, IEC-6. It was con?rmed that both xanthohumol and isoxanthohumol inhibited cell proliferation, even at micromolar concentrations. For cell line HT-29, the IC50 was 1.2 +- 0.9 and 16.9 +- 0.9mýmol dm 3 for xanthohumol and isoxanthohumol, respectively. Similar values were obtained for SW620 cells (2.5 +- 0.2 and 37.3 +- 3.2mýmol dm-3). None of the pure prenyl?avonoids that were tested affected the proliferation of the noncancerous cell line, IEC-6. The effect of the hop extract containing xanthohumol was also tested for antiproliferative activities on the cancer cell lines, HT-29 (IC50= 3.1 +- 0.2mýmol dm-3 ) and SW620 (IC50= 1 +- 0.2mýmol dm-3), and on the cell line, IEC-6 (IC50= 65.5 +- 11.3mýmol dm-3). The results showed a similar trend to that for pure compounds, suggesting a possible future application of hop extracts in the pharmaceutical industry. (en)
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| Title
| - Antiproliferative effects of prenylflavonoids from hops on human colon cancer cell lines
- Antiproliferative effects of prenylflavonoids from hops on human colon cancer cell lines (en)
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| skos:prefLabel
| - Antiproliferative effects of prenylflavonoids from hops on human colon cancer cell lines
- Antiproliferative effects of prenylflavonoids from hops on human colon cancer cell lines (en)
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| skos:notation
| - RIV/60461373:22330/14:43897047!RIV15-MZE-22330___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22330/14:43897047
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - colon cancer; antiproliferative; isoxanthohumol; xanthohumol; prenyl?avonoids; hop (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of the Institute of Brewing
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Dostálek, Pavel
- Hudcová, Tereza
- Jelínek, Lukáš
- Karabín, Marcel
- Fiala, Jaromír
- Bryndová, Jana
- Fialová, Kristýna
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| http://linked.open...ain/vavai/riv/wos
| |
| issn
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| number of pages
| |
| http://bibframe.org/vocab/doi
| |
| http://localhost/t...ganizacniJednotka
| |
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