About: Amides derived from heteroaromatic amines and selected steryl hemiesters

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 mu M (8) and 23.1 +/- 4.0 mu M (9)] and cervical cancer [24.8 +/- 5.3 mu M (8) and 29.1 +/- 4.7 mu M (9)]. Only the compound 8 was adequately less active on normal human fibroblasts (40.4 +/- 11.1 mu M). The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 mu M (8) and 23.1 +/- 4.0 mu M (9)] and cervical cancer [24.8 +/- 5.3 mu M (8) and 29.1 +/- 4.7 mu M (9)]. Only the compound 8 was adequately less active on normal human fibroblasts (40.4 +/- 11.1 mu M). (en)
Title	Amides derived from heteroaromatic amines and selected steryl hemiesters Amides derived from heteroaromatic amines and selected steryl hemiesters (en)
skos:prefLabel	Amides derived from heteroaromatic amines and selected steryl hemiesters Amides derived from heteroaromatic amines and selected steryl hemiesters (en)
skos:notation	RIV/60461373:22330/13:43895382!RIV14-GA0-22330___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(ED0007/01/01), P(GAP503/11/0616), Z(MSM6046137305)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Wimmer, Zdeněk Bildziukevich, Uladzimir Drašar, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	60231
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/13:43895382
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytotoxic activity; Amide; Lanosterol; Cholesterol; Heteroaromatic amine (en)
http://linked.open.../riv/klicoveSlovo	Heteroaromatic amine Lanosterol Amide Cholesterol Cytotoxic activity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CC3D39E7B4D7]
http://linked.open...i/riv/nazevZdroje	Steroids
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Antimycobacterial and Antimicrobial Agents and Plant Elicitors Inspired by Natural Products of Insect Symbionts Centre of the Region Haná for Biotechnological and Agricultural Research
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	78
http://linked.open...iv/tvurceVysledku	Havlíček, Libor Šaman, David Drašar, Pavel Rárová, Lucie Bildziukevich, Uladzimir Wimmer, Zdenek
http://linked.open...ain/vavai/riv/wos	000328303300006
http://linked.open...n/vavai/riv/zamer	Teoretické základy potravinářských a biochemických technologií
issn	0039-128X
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.steroids.2013.10.003
http://localhost/t...ganizacniJednotka	22330

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