About: Modified approach for preparing (E)-stilbenes related to resveratrol and evaluation of their potencial immunobiologal effect

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Resveratrol and closely related stilbenoids belong to the most intensively studied biologically active compounds. This interest evoked several attempts to prepare such compounds in a convenient synthetic way. Our approach allowed obtaining largely methoxystilbenes, formed as (E)-isomers only (using Wittig-Horner synthesis as the key step), which were further demethylated by boron tribromide. The hydroxymethoxystilbenes (e.g. pterostilbene) were prepared using isopropyl protection groups, later selectively deprotected by boron trichloride. The method is suitable for preparing such compounds in a large amount. Effects of the obtained stilbene derivatives on immunobiological responses triggered by lipopolysacharide and interferon- were tested under in vitro conditions. Namely production of nitric oxide (NO) was investigated, and relation between the molecular structure and immunobiological activity was assessed. Resveratrol and closely related stilbenoids belong to the most intensively studied biologically active compounds. This interest evoked several attempts to prepare such compounds in a convenient synthetic way. Our approach allowed obtaining largely methoxystilbenes, formed as (E)-isomers only (using Wittig-Horner synthesis as the key step), which were further demethylated by boron tribromide. The hydroxymethoxystilbenes (e.g. pterostilbene) were prepared using isopropyl protection groups, later selectively deprotected by boron trichloride. The method is suitable for preparing such compounds in a large amount. Effects of the obtained stilbene derivatives on immunobiological responses triggered by lipopolysacharide and interferon- were tested under in vitro conditions. Namely production of nitric oxide (NO) was investigated, and relation between the molecular structure and immunobiological activity was assessed. (en)
Title	Modified approach for preparing (E)-stilbenes related to resveratrol and evaluation of their potencial immunobiologal effect Modified approach for preparing (E)-stilbenes related to resveratrol and evaluation of their potencial immunobiologal effect (en)
skos:prefLabel	Modified approach for preparing (E)-stilbenes related to resveratrol and evaluation of their potencial immunobiologal effect Modified approach for preparing (E)-stilbenes related to resveratrol and evaluation of their potencial immunobiologal effect (en)
skos:notation	RIV/60461373:22330/10:00024454!RIV11-GA0-22330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/07/1227), Z(AV0Z40550506), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Merkl, Roman Filip, Vladimír Šmidrkal, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	272239
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/10:00024454
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	resveratrol; synthesis; hydroxymethoxystilbene; immunobiological activity (en)
http://linked.open.../riv/klicoveSlovo	hydroxymethoxystilbene synthesis immunobiological activity resveratrol
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[608536707320]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	GM
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Photochemical preparation of oligomeric analogues of natural resveratrol derivatives and related stilbenoids
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	75
http://linked.open...iv/tvurceVysledku	Filip, Vladimír Merkl, Roman Šmidrkal, Jan Zídek, Z. Harmatha, J. Budyšínský, M. Komníčková, E. Vokáč, K.
http://linked.open...ain/vavai/riv/wos	000277125800003
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0010-0765
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	22330

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