About: Genomic damage induced in tobacco plants by chlorobenzoic acids-Metabolic products of polychlorinated biphenyls

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About: Genomic damage induced in tobacco plants by chlorobenzoic acids-Metabolic products of polychlorinated biphenyls Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tobacco seedlings (Nicotiana tabacum var. xanthi) were treated for 24 h with mono-(2- and 3-CBA), di-(2,5- and 3,4-CBA), and tri-(2,4,6- and 2,3,5-CBA)-chlorobenzoic acids (CBAs) and with the mixture of polychlorinated biphenyls - Delor 103, or cultivated for 1 or 2 weeks in soil polluted with the CBAs. DNA damage in nuclei of leaves and roots was evaluated by the comet assay. A significant increase in DNA damage was observed only at concentrations of CBAs that caused withering of leaves or had lethal effects within 2-4 weeks after the treatments. As the application of CBAs did not induce somatic mutations, the induced DNA migration is probably caused by necrotic DNA fragmentation and not by DNA damage resulting in genetic alteration. In contrast, the application of the monofunctional alkylating agent ethyl methanesulphonate as a positive control resulted in a dose-response increase of DNA damage and an increase of somatic mutations. Thus. the EMS-produced DNA migration is probably associated with gen Tobacco seedlings (Nicotiana tabacum var. xanthi) were treated for 24 h with mono-(2- and 3-CBA), di-(2,5- and 3,4-CBA), and tri-(2,4,6- and 2,3,5-CBA)-chlorobenzoic acids (CBAs) and with the mixture of polychlorinated biphenyls - Delor 103, or cultivated for 1 or 2 weeks in soil polluted with the CBAs. DNA damage in nuclei of leaves and roots was evaluated by the comet assay. A significant increase in DNA damage was observed only at concentrations of CBAs that caused withering of leaves or had lethal effects within 2-4 weeks after the treatments. As the application of CBAs did not induce somatic mutations, the induced DNA migration is probably caused by necrotic DNA fragmentation and not by DNA damage resulting in genetic alteration. In contrast, the application of the monofunctional alkylating agent ethyl methanesulphonate as a positive control resulted in a dose-response increase of DNA damage and an increase of somatic mutations. Thus. the EMS-produced DNA migration is probably associated with gen (en)
Title	Genomic damage induced in tobacco plants by chlorobenzoic acids-Metabolic products of polychlorinated biphenyls Genomic damage induced in tobacco plants by chlorobenzoic acids-Metabolic products of polychlorinated biphenyls (en)
skos:prefLabel	Genomic damage induced in tobacco plants by chlorobenzoic acids-Metabolic products of polychlorinated biphenyls Genomic damage induced in tobacco plants by chlorobenzoic acids-Metabolic products of polychlorinated biphenyls (en)
skos:notation	RIV/60461373:22330/08:00021360!RIV10-MSM-22330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/06/0563), P(GA521/05/0500), Z(AV0Z50380511), Z(MSM6046137305)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lovecká, Petra Vrchotová, Blanka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	369172
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/08:00021360
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Comet assay; Delor 103; Ethyl methanesulphonate; Nicotiana tabacum L. var. xanthi; Somatic mutations (en)
http://linked.open.../riv/klicoveSlovo	Comet assay Delor 103 Nicotiana tabacum L. var. xanthi Somatic mutations Ethyl methanesulphonate
http://linked.open...odStatuVydavatele	BE - Belgické království
http://linked.open...ontrolniKodProRIV	[8F5D26CEAF16]
http://linked.open...i/riv/nazevZdroje	Mutation Research/Genetic Toxicology and Environmental Mutagenesis
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Induced DNA damage, mutagenicity, homologous recombination and apoptosis as endpoints for monitoring effects of pollutants in tobacco and potato Metabolism of chlorinated xenobiotics in plants
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	657
http://linked.open...iv/tvurceVysledku	Lovecká, Petra Vrchotová, Blanka Gicner, Tomáš
http://linked.open...ain/vavai/riv/wos	000261851000009
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Teoretické základy potravinářských a biochemických technologií
issn	1383-5718
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	22330

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