About: Activity of translation system and abundance of tmRNA during development of Streptomyces aureofaciens producing tetracycline

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Transition from exponential phase of growth to stationary phase in Streptomyces aureofaciens is characterized by a decrease in the rate of translation and induction of tetracycline (Ttc) biosynthesis. In exponential phase, no significant changes were found in the activity of ribosomes at binding of ternary complex Phe-tRNA.EF-Tu.GTP to the A-site on ribosomes. Overexpression of Ttc in stationary phase is accompanied by a decrease in the binding of the ternary complex Phe-tRNA.EF-Tu.GTP to the A-site of ribosome and a formation of an aggregate with Tic by part of the ribosomes. Antibiotics that cause ribosome to stall or pause could increase the requirement for tmRNA in the process called trans-translation. We found differences in the level of tmRNA during the development of S. aureofaciens. Subinhibitory concentrations of Tic, streptomycin and chloramphenicol induced an increase in the tmRNA level in cells from the exponential phase of growth. In vitro trans-translation system of S. aureofaciens was s Transition from exponential phase of growth to stationary phase in Streptomyces aureofaciens is characterized by a decrease in the rate of translation and induction of tetracycline (Ttc) biosynthesis. In exponential phase, no significant changes were found in the activity of ribosomes at binding of ternary complex Phe-tRNA.EF-Tu.GTP to the A-site on ribosomes. Overexpression of Ttc in stationary phase is accompanied by a decrease in the binding of the ternary complex Phe-tRNA.EF-Tu.GTP to the A-site of ribosome and a formation of an aggregate with Tic by part of the ribosomes. Antibiotics that cause ribosome to stall or pause could increase the requirement for tmRNA in the process called trans-translation. We found differences in the level of tmRNA during the development of S. aureofaciens. Subinhibitory concentrations of Tic, streptomycin and chloramphenicol induced an increase in the tmRNA level in cells from the exponential phase of growth. In vitro trans-translation system of S. aureofaciens was s (en)
Title	Activity of translation system and abundance of tmRNA during development of Streptomyces aureofaciens producing tetracycline Activity of translation system and abundance of tmRNA during development of Streptomyces aureofaciens producing tetracycline (en)
skos:prefLabel	Activity of translation system and abundance of tmRNA during development of Streptomyces aureofaciens producing tetracycline Activity of translation system and abundance of tmRNA during development of Streptomyces aureofaciens producing tetracycline (en)
skos:notation	RIV/60461373:22330/06:00022547!RIV10-MSM-22330___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA203/05/0106), S, Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	51
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Feglarová, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	464093
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/06:00022547
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PROTEIN-SYNTHESIS INHIBITORS; ESCHERICHIA-COLI; TRANS-TRANSLATION; MESSENGER-RNA; RIBOSOMAL-SUBUNIT; STOP CODONS; SSRA TMRNA; DEGRADATION; BINDING; SMPB (en)
http://linked.open.../riv/klicoveSlovo	BINDING ESCHERICHIA-COLI MESSENGER-RNA DEGRADATION PROTEIN-SYNTHESIS INHIBITORS RIBOSOMAL-SUBUNIT SMPB SSRA TMRNA STOP CODONS TRANS-TRANSLATION
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[FD189AAF8A5D]
http://linked.open...i/riv/nazevZdroje	Folia Microbiologica
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of trans-translation in cellular differentiation and resistance to produced antibiotics in Streptomycetes
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Bobek, Jan Felsberg, J. Mikulik, Karel Palečková, Petra
http://linked.open...ain/vavai/riv/wos	000244260100002
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0015-5632
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	22330

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