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rdf:type
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Description
| - The amyloid beta peptide suffers from the highly selective attack of H-radical atoms on the Met35 residue, with the formation of a modified peptide containing an a-aminobutyric acid residue. This chemical reactivity could represent the molecular basis of a posttranslational modification of the amyloid beta peptide which could infer interesting biological effects. The formation of trans-lipids as a marker of radical damage to methionine-containing peptides was also evaluated. The system of 1-palmitoyl-2-oleoyl phosphatidylcholine vesicles containing amyloid beta peptide modeled the occurrence of radical damage that is transferred from the peptide to the lipid domain. This suggests a link between lipidomics and proteomics, due to the known interaction of the amyloid beta protein with cell membranes.
- The amyloid beta peptide suffers from the highly selective attack of H-radical atoms on the Met35 residue, with the formation of a modified peptide containing an a-aminobutyric acid residue. This chemical reactivity could represent the molecular basis of a posttranslational modification of the amyloid beta peptide which could infer interesting biological effects. The formation of trans-lipids as a marker of radical damage to methionine-containing peptides was also evaluated. The system of 1-palmitoyl-2-oleoyl phosphatidylcholine vesicles containing amyloid beta peptide modeled the occurrence of radical damage that is transferred from the peptide to the lipid domain. This suggests a link between lipidomics and proteomics, due to the known interaction of the amyloid beta protein with cell membranes. (en)
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Title
| - Reductive modification of a methionine residue
- Reductive modification of a methionine residue (en)
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skos:prefLabel
| - Reductive modification of a methionine residue
- Reductive modification of a methionine residue (en)
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skos:notation
| - RIV/60461373:22330/06:00022544!RIV10-MSM-22330___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22330/06:00022544
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - lipids; methionine; peptides; radicals; radiolysis (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Angewandte Chemie-International Edition
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Kodíček, Milan
- Kadlčík, Vojtěch
- Chatgilialoglu, Chryssostomos
- Ferreri, Carla
- Houée-Levin, Chantal
- Sicard-Roselli, Cécile
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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