About: Reductive modification of a methionine residue

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The amyloid beta peptide suffers from the highly selective attack of H-radical atoms on the Met35 residue, with the formation of a modified peptide containing an a-aminobutyric acid residue. This chemical reactivity could represent the molecular basis of a posttranslational modification of the amyloid beta peptide which could infer interesting biological effects. The formation of trans-lipids as a marker of radical damage to methionine-containing peptides was also evaluated. The system of 1-palmitoyl-2-oleoyl phosphatidylcholine vesicles containing amyloid beta peptide modeled the occurrence of radical damage that is transferred from the peptide to the lipid domain. This suggests a link between lipidomics and proteomics, due to the known interaction of the amyloid beta protein with cell membranes. The amyloid beta peptide suffers from the highly selective attack of H-radical atoms on the Met35 residue, with the formation of a modified peptide containing an a-aminobutyric acid residue. This chemical reactivity could represent the molecular basis of a posttranslational modification of the amyloid beta peptide which could infer interesting biological effects. The formation of trans-lipids as a marker of radical damage to methionine-containing peptides was also evaluated. The system of 1-palmitoyl-2-oleoyl phosphatidylcholine vesicles containing amyloid beta peptide modeled the occurrence of radical damage that is transferred from the peptide to the lipid domain. This suggests a link between lipidomics and proteomics, due to the known interaction of the amyloid beta protein with cell membranes. (en)
Title	Reductive modification of a methionine residue Reductive modification of a methionine residue (en)
skos:prefLabel	Reductive modification of a methionine residue Reductive modification of a methionine residue (en)
skos:notation	RIV/60461373:22330/06:00022544!RIV10-MSM-22330___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	16
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kadlčík, Vojtěch Kodíček, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	496798
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/06:00022544
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lipids; methionine; peptides; radicals; radiolysis (en)
http://linked.open.../riv/klicoveSlovo	peptides methionine radiolysis lipids radicals
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[55E2DB3EE0C3]
http://linked.open...i/riv/nazevZdroje	Angewandte Chemie-International Edition
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...iv/tvurceVysledku	Kodíček, Milan Kadlčík, Vojtěch Chatgilialoglu, Chryssostomos Ferreri, Carla Houée-Levin, Chantal Sicard-Roselli, Cécile
http://linked.open...ain/vavai/riv/wos	000236815700025
issn	1433-7851
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	22330

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