About: Tyrosine Residues Modifications Studied by MALDI-TOF MS

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tyrosine residue is often a target of biologically interesting posttranslational modifications. Among them, phosphorylation, which plays pivotal roles in regulation of protein activity and thus also in signal transduction pathways, and nitration, which is associated with oxidative stress, are believed to be the most important ones.In the first part of this study we used chemical modification of tyrosine residues of model proteins by tetranitomethane to verify the possibility to detect localization of aromatic groups on the surface of protein globule. The modified tyrosine residues were localized by tryptic cleavage and MALDI-TOF MS. The method for determination of surface tyrosine residues which represent potential targets for posttranslational modifications was developed. Secondly we localized natural occuring posttranslational phosphorylation of plant phospholipase D from Brasica oleracea var capitata. This was performed by comparison of MALDI-TOF MS spectra of tryptic digests of phosphorylated form Tyrosine residue is often a target of biologically interesting posttranslational modifications. Among them, phosphorylation, which plays pivotal roles in regulation of protein activity and thus also in signal transduction pathways, and nitration, which is associated with oxidative stress, are believed to be the most important ones.In the first part of this study we used chemical modification of tyrosine residues of model proteins by tetranitomethane to verify the possibility to detect localization of aromatic groups on the surface of protein globule. The modified tyrosine residues were localized by tryptic cleavage and MALDI-TOF MS. The method for determination of surface tyrosine residues which represent potential targets for posttranslational modifications was developed. Secondly we localized natural occuring posttranslational phosphorylation of plant phospholipase D from Brasica oleracea var capitata. This was performed by comparison of MALDI-TOF MS spectra of tryptic digests of phosphorylated form (en) Studium modifikací tyrosinu pomocí MALDI-TOF MS (cs)
Title	Tyrosine Residues Modifications Studied by MALDI-TOF MS Tyrosine Residues Modifications Studied by MALDI-TOF MS (en) Studium modifikací tyrosinu pomocí MALDI-TOF MS (cs)
skos:prefLabel	Tyrosine Residues Modifications Studied by MALDI-TOF MS Tyrosine Residues Modifications Studied by MALDI-TOF MS (en) Studium modifikací tyrosinu pomocí MALDI-TOF MS (cs)
skos:notation	RIV/60461373:22330/04:00012918!RIV/2005/GA0/223305/N
http://linked.open.../vavai/riv/strany	50
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/02/0922), Z(MSM 223300006)
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Novotná, Zuzana Šantrůček, Jiří Kadlčík, Vojtěch Hynek, Radovan Kodíček, Milan
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	591123
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/04:00012918
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tyrosine phosphorylation (en)
http://linked.open.../riv/klicoveSlovo	tyrosine phosphorylation
http://linked.open...ontrolniKodProRIV	[FFA7FF23E83C]
http://linked.open...v/mistoKonaniAkce	Santa Fe - New Mexico - USA
http://linked.open...i/riv/mistoVydani	Santa Fe - New Mexico - USA
http://linked.open...i/riv/nazevZdroje	Mass Spectrometry in Systems Biology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Application of MALDI-TOF (matrix assisted laser desorption ionisation - Time of Flight) mass spectrometry on the determination of protein conformation
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Hynek, Radovan Kodíček, Milan Šantrůček, Jiří Novotná, Zuzana Kadlčík, Vojtěch
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2004-02-14 (xsd:date)
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223300006
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Neuveden
http://localhost/t...ganizacniJednotka	22330

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