About: Assembly of M-PMV retroviral capsids in vitro

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Retroviruses are subject of intensive studies not only in context with AIDS pandemia and oncogenic effect on several organisms including human. The understanding of retroviral capsid assembly mechanisms and nucleic acids incorporation could significantly contribute to further use of these systems for therapeutic purposes. Our research is focused on study of forming of Mason-Pfizer monkey virus (M-PMV) immature capsids in vitro. M PMV as the prototype of D-type retrovirus is an excellent model for assembly studies. These retroviruses are characterized by the assembly of intracytoplasmic capsids, which make their way to the plasma membrane and are released by budding. Gag polyproteins of all retroviruses contain domains corresponding to the structural proteins which are important for driving the assembly process, namely matrix (MA), capsid (CA) and nucleocapsid (NC) proteins.We have found specific conditions under which we can prepare properly assembled capsids in vitro from structural polyprotein Gag a Retroviruses are subject of intensive studies not only in context with AIDS pandemia and oncogenic effect on several organisms including human. The understanding of retroviral capsid assembly mechanisms and nucleic acids incorporation could significantly contribute to further use of these systems for therapeutic purposes. Our research is focused on study of forming of Mason-Pfizer monkey virus (M-PMV) immature capsids in vitro. M PMV as the prototype of D-type retrovirus is an excellent model for assembly studies. These retroviruses are characterized by the assembly of intracytoplasmic capsids, which make their way to the plasma membrane and are released by budding. Gag polyproteins of all retroviruses contain domains corresponding to the structural proteins which are important for driving the assembly process, namely matrix (MA), capsid (CA) and nucleocapsid (NC) proteins.We have found specific conditions under which we can prepare properly assembled capsids in vitro from structural polyprotein Gag a (en) Skládání MPMV kapsid in vitro (cs)
Title	Assembly of M-PMV retroviral capsids in vitro Assembly of M-PMV retroviral capsids in vitro (en) Skládání MPMV kapsid in vitro (cs)
skos:prefLabel	Assembly of M-PMV retroviral capsids in vitro Assembly of M-PMV retroviral capsids in vitro (en) Skládání MPMV kapsid in vitro (cs)
skos:notation	RIV/60461373:22330/04:00012742!RIV/2005/MSM/223305/N
http://linked.open.../vavai/riv/strany	96-97
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LN00A079)
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Suchanová, Šárka Rumlová, Michaela Ulbrich, Pavel Ruml, Tomáš
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	555431
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/04:00012742
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CA-NC protein;in vitro assembly (en)
http://linked.open.../riv/klicoveSlovo	in vitro assembly CA-NC protein
http://linked.open...ontrolniKodProRIV	[F311F79FBEE5]
http://linked.open...v/mistoKonaniAkce	Olomouc
http://linked.open...i/riv/mistoVydani	Olomouc
http://linked.open...i/riv/nazevZdroje	Proceedings of the XIX. meeting of czech and slovak societies for biochemistry and molecular biology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Integrated Genomics
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Ruml, Tomáš Rumlová, Michaela Ulbrich, Pavel Haubová, Šárka
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2004-01-01 (xsd:date)
issn	0232-0061
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Univerzita Palackého v Olomouci
http://localhost/t...ganizacniJednotka	22330

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