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rdf:type
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Description
| - Enzymes from cold adapted microorganisms are being studied as potential catalysts in biotechnology as well as models of adaptation on an evolutionary level. The relationship between structural features of these enzymes and their ability to efficiently catalyse reactions at low temperatures is not clear. A study of beta-galactosidase from Antarctic bacteria Arthrobacter sp. C2-2 is presented. Model of 3D-structure of this enzyme was built using a methodology of homology modelling by satisfaction of spatial restraints based on structure of beta-galactosidase from E. coli (1DP0), the structure of one loop region was predicted ab initio. Interactions between the enzyme and ligands (galactose, water and ions) was studied using a methodology of molecular fields, docking, molecular dynamics simulation and free-energy scoring. Overall quality of the model was evaluated by 1 ns molecular dynamics simulation. We present comparison of structural features of the studied enzyme and its mesophilic counterpart from
- Enzymes from cold adapted microorganisms are being studied as potential catalysts in biotechnology as well as models of adaptation on an evolutionary level. The relationship between structural features of these enzymes and their ability to efficiently catalyse reactions at low temperatures is not clear. A study of beta-galactosidase from Antarctic bacteria Arthrobacter sp. C2-2 is presented. Model of 3D-structure of this enzyme was built using a methodology of homology modelling by satisfaction of spatial restraints based on structure of beta-galactosidase from E. coli (1DP0), the structure of one loop region was predicted ab initio. Interactions between the enzyme and ligands (galactose, water and ions) was studied using a methodology of molecular fields, docking, molecular dynamics simulation and free-energy scoring. Overall quality of the model was evaluated by 1 ns molecular dynamics simulation. We present comparison of structural features of the studied enzyme and its mesophilic counterpart from (en)
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Title
| - Beta-Galactosidase from Antarctic bacterium Arthrobacter sp. C2-2: a molecular modelling study - sborník
- Beta-Galactosidase from Antarctic bacterium Arthrobacter sp. C2-2: a molecular modelling study - sborník (en)
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skos:prefLabel
| - Beta-Galactosidase from Antarctic bacterium Arthrobacter sp. C2-2: a molecular modelling study - sborník
- Beta-Galactosidase from Antarctic bacterium Arthrobacter sp. C2-2: a molecular modelling study - sborník (en)
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skos:notation
| - RIV/60461373:22330/03:00008979!RIV/2004/GA0/223304/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22330/03:00008979
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Psychrotrophic microorganisms (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Spiwok, Vojtěch
- Strnad, Hynek
- Králová, Blanka
- Malá, Šárka
- Karasová, Petra
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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number of pages
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http://purl.org/ne...btex#hasPublisher
| - Vysoká škola chemicko-technologická v Praze
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https://schema.org/isbn
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http://localhost/t...ganizacniJednotka
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