About: Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat

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About: Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance. To further investigate the effects of resistin on glucose metabolism, we derived a novel transgenic strain of spontaneously hypertensive rats expressing the mouse resistin gene under the control of the fat-specific aP2 promoter and also performed in vitro studies of the effects of recombinant resistin on glucose metabolism in isolated skeletal muscle. Expression of the resistin transgene was detected by Northern blot analysis in adipose tissue and by real-time PCR in skeletal muscle and was associated with increased serum fatty acids and muscle triglycerides, impaired skeletal muscle glucose metabolism, and glucose intolerance in the absence of any changes in serum resistin concentrations. In skeletal muscle isolated from non-transgenic spontaneously hypertensive rats, in vitro incubation with recombinant resistin significantly inhibited insuli Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance. To further investigate the effects of resistin on glucose metabolism, we derived a novel transgenic strain of spontaneously hypertensive rats expressing the mouse resistin gene under the control of the fat-specific aP2 promoter and also performed in vitro studies of the effects of recombinant resistin on glucose metabolism in isolated skeletal muscle. Expression of the resistin transgene was detected by Northern blot analysis in adipose tissue and by real-time PCR in skeletal muscle and was associated with increased serum fatty acids and muscle triglycerides, impaired skeletal muscle glucose metabolism, and glucose intolerance in the absence of any changes in serum resistin concentrations. In skeletal muscle isolated from non-transgenic spontaneously hypertensive rats, in vitro incubation with recombinant resistin significantly inhibited insuli (en)
Title	Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat (en)
skos:prefLabel	Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat (en)
skos:notation	RIV/60461373:22330/03:00008965!RIV/2004/GA0/223304/N
http://linked.open.../vavai/riv/strany	45209-15
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA301/03/0751)
http://linked.open...iv/cisloPeriodika	46
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Mlejnek, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	631338
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/03:00008965
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Proteins; Muscle; Genetic engineering; Living systems studies; Cells; Oils and fats; Insulin; Metabolism; Glucose; Genes; Fatty acids; (en)
http://linked.open.../riv/klicoveSlovo	Proteins Muscle Genes Glucose Fatty acids Metabolism Insulin Cells Genetic engineering Living systems studies Oils and fats
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[607FF59A434B]
http://linked.open...i/riv/nazevZdroje	The Journal of biological chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Transgenic analysis of the resistin effects on cyrbohydrate and lipid metabolism in spontaneously hypertensive rats
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	278
http://linked.open...iv/tvurceVysledku	Jansa, Petr Mlejnek, Petr Pravenec, Michal Zídek, Václav Kazdová, Ludmila Landa, Vladimir Kurtz, Theodore Wang, Jiaming
issn	0021-9258
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	22330

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