About: Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae: inhibition with peptidomimetic inhibitors.     Goto   Sponge   NotDistinct   Permalink

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Description
  • The secretion of aspartic proteases by Candida spp. was demonstrated to be one of the virulence determinants. Candida albicans is classified in the genus Candida as the major human pathogen. However, other species of this genus cause a candidiases. We designed and prepared an inhibitor containing phenylstatine isoster that was equipotent towards all four proteases within the range of 10-10 - 10-9 M. The HIV-1 protease inhibitors were also tested for the inhibition of four Saps.
  • The secretion of aspartic proteases by Candida spp. was demonstrated to be one of the virulence determinants. Candida albicans is classified in the genus Candida as the major human pathogen. However, other species of this genus cause a candidiases. We designed and prepared an inhibitor containing phenylstatine isoster that was equipotent towards all four proteases within the range of 10-10 - 10-9 M. The HIV-1 protease inhibitors were also tested for the inhibition of four Saps. (en)
Title
  • Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae: inhibition with peptidomimetic inhibitors.
  • Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae: inhibition with peptidomimetic inhibitors. (en)
skos:prefLabel
  • Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae: inhibition with peptidomimetic inhibitors.
  • Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae: inhibition with peptidomimetic inhibitors. (en)
skos:notation
  • RIV/60461373:22330/01:00004481!RIV/2004/MSM/223304/N
http://linked.open.../vavai/riv/strany
  • 2669;2677
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LN00A079)
http://linked.open...iv/cisloPeriodika
  • 268
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 695362
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22330/01:00004481
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Inhibition, protease, Candida (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [BFF2604A08AF]
http://linked.open...i/riv/nazevZdroje
  • Europian Journal of Biochemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • Neuveden
http://linked.open...iv/tvurceVysledku
  • Dostál, Jiří
  • Pichová, Iva
  • Ruml, Tomáš
  • Hrušková-Heidingsfeldová, Olga
  • Pavlíčková, Libuše
  • Dolejší, Elena
issn
  • 0014-2956
number of pages
http://localhost/t...ganizacniJednotka
  • 22330
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