About: DEGRADATION PRODUCTS OF PHARMACEUTICAL SUBSTANCES IN THE ELECTRIC FIELD

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.icct.cz/proceedings/2014/Full_Papers_ICCT_2014.pdf
Description	Pharmaceutical powders are prone to electrostatic charging by interact particles with equipment surface and the surface of other particles. The electrostatic charge of pharmaceutical powder particles affects properties of a raw material and all powder handling procedures, as the generated charge affects character and purity of final dosage form. The effect of electrostatic charge on composition of charged pharmaceutical substances was studied. The experimental charging was performed on samples of selected pharmaceutical substances and the charge was simulated by placing the samples in an electric field. The tested substances are morphinan alkaloids and trospium chloride. The electric fields were generated in two ways - corona discharge (2-10 kV) and by voltage (15 kV) applied to electrodes attached to a glass horizontal tube. The experimental parameters were chosen to determination relationship between degradation process and the size of applied voltage, the period of charging or the composition of atmosphere around the sample. Our analysis showed increase of degradation products of morphinan alkaloids and inversion of the relative configuration of trospium chloride. The electric field accelerates degradation process. We presume the degradation reactions took place only on free surface of a bulk material situated in a sample vessel. Degradation reactions did not occur in rest of the bulk material. In relation to our results, the free surface of a powder material has important role in the degradation process. Pharmaceutical powders are prone to electrostatic charging by interact particles with equipment surface and the surface of other particles. The electrostatic charge of pharmaceutical powder particles affects properties of a raw material and all powder handling procedures, as the generated charge affects character and purity of final dosage form. The effect of electrostatic charge on composition of charged pharmaceutical substances was studied. The experimental charging was performed on samples of selected pharmaceutical substances and the charge was simulated by placing the samples in an electric field. The tested substances are morphinan alkaloids and trospium chloride. The electric fields were generated in two ways - corona discharge (2-10 kV) and by voltage (15 kV) applied to electrodes attached to a glass horizontal tube. The experimental parameters were chosen to determination relationship between degradation process and the size of applied voltage, the period of charging or the composition of atmosphere around the sample. Our analysis showed increase of degradation products of morphinan alkaloids and inversion of the relative configuration of trospium chloride. The electric field accelerates degradation process. We presume the degradation reactions took place only on free surface of a bulk material situated in a sample vessel. Degradation reactions did not occur in rest of the bulk material. In relation to our results, the free surface of a powder material has important role in the degradation process. (en)
Title	DEGRADATION PRODUCTS OF PHARMACEUTICAL SUBSTANCES IN THE ELECTRIC FIELD DEGRADATION PRODUCTS OF PHARMACEUTICAL SUBSTANCES IN THE ELECTRIC FIELD (en)
skos:prefLabel	DEGRADATION PRODUCTS OF PHARMACEUTICAL SUBSTANCES IN THE ELECTRIC FIELD DEGRADATION PRODUCTS OF PHARMACEUTICAL SUBSTANCES IN THE ELECTRIC FIELD (en)
skos:notation	RIV/60461373:22310/14:43898269!RIV15-MSM-22310___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kratochvíl, Bohumil Gruberová, Lucie
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	10068
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/14:43898269
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	degradation; pharmaceutical powders; electric field; corona discharge; electrostatic charge (en)
http://linked.open.../riv/klicoveSlovo	degradation corona discharge electric field electrostatic charge pharmaceutical powders
http://linked.open...ontrolniKodProRIV	[0DA1CC5FA2C6]
http://linked.open...v/mistoKonaniAkce	Mikulov, Czech Republic
http://linked.open...i/riv/mistoVydani	Prague
http://linked.open...i/riv/nazevZdroje	Proceedings of the 2nd International Conference on Chemical Technology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Kratochvíl, Bohumil Jegorov, Alexandr Gruberová, Lucie
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2014-04-07 (xsd:date)
number of pages	5 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Ocean Design
https://schema.org/isbn	978-80-86238-64-7
http://localhost/t...ganizacniJednotka	22310

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