About: Increasing dissolution of trospium chloride by co-crystallization with urea

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The search for various solid forms of an active pharmaceutical ingredient (API) is an important step in drug development. Our aim was to prepare co-crystals of trospium chloride, an anticholinergic drug used for the treatment of incontinence, and to investigate if they have advantageous properties for drug formulation. Phase identification was done by powder X-ray diffraction and single-crystal X-ray diffraction. The chemical composition was verified by solution NMR and the dissolution rate of the prepared phases was studied by IDR (intrinsic dissolution rate). For further analysis of phase stability and transitions, combined thermal analysis and temperature-resolved X-ray powder diffraction were used. Urea was selected as a co-crystallization partner. Trospium chloride urea (1:1) co-crystal was prepared by a solvent evaporation. from single-crystal data, the co-crystal structure was solved in a space group P2(1)/c and compared to previously published structures of trospium chloride. Intrinsic dissolution rate revealed that the co-crystal dissolves 32% faster than pure API. However, its low thermal and pressure stability makes it a challenging choice for the final drug formulation. (C) 2014 Elsevier By. All rights reserved. The search for various solid forms of an active pharmaceutical ingredient (API) is an important step in drug development. Our aim was to prepare co-crystals of trospium chloride, an anticholinergic drug used for the treatment of incontinence, and to investigate if they have advantageous properties for drug formulation. Phase identification was done by powder X-ray diffraction and single-crystal X-ray diffraction. The chemical composition was verified by solution NMR and the dissolution rate of the prepared phases was studied by IDR (intrinsic dissolution rate). For further analysis of phase stability and transitions, combined thermal analysis and temperature-resolved X-ray powder diffraction were used. Urea was selected as a co-crystallization partner. Trospium chloride urea (1:1) co-crystal was prepared by a solvent evaporation. from single-crystal data, the co-crystal structure was solved in a space group P2(1)/c and compared to previously published structures of trospium chloride. Intrinsic dissolution rate revealed that the co-crystal dissolves 32% faster than pure API. However, its low thermal and pressure stability makes it a challenging choice for the final drug formulation. (C) 2014 Elsevier By. All rights reserved. (en)
Title	Increasing dissolution of trospium chloride by co-crystallization with urea Increasing dissolution of trospium chloride by co-crystallization with urea (en)
skos:prefLabel	Increasing dissolution of trospium chloride by co-crystallization with urea Increasing dissolution of trospium chloride by co-crystallization with urea (en)
skos:notation	RIV/60461373:22310/14:43897874!RIV15-GA0-22310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GA14-03636S), S
http://linked.open...iv/cisloPeriodika	AUG 1 2014
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Hušák, Michal Čejka, Jan Skořepová, Eliška Zámostný, Petr Kratochvíl, Bohumil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	21152
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/14:43897874
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Organic compounds; Growth from solutions; X-ray diffraction; Solubility; Crystal structure (en)
http://linked.open.../riv/klicoveSlovo	Growth from solutions Crystal structure X-ray diffraction Solubility Organic compounds
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[ED7E64B994EB]
http://linked.open...i/riv/nazevZdroje	Journal Cryst.Growth
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Příprava a charakterizace pokročilých vícesložkových farmaceutických systémů s řízenými fyzikálně-chemickými vlastnostmi
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	399
http://linked.open...iv/tvurceVysledku	Zámostný, Petr Kratochvíl, Bohumil Čejka, Jan Skořepová, Eliška Hušák, Michal
http://linked.open...ain/vavai/riv/wos	000336432400004
issn	0022-0248
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jcrysgro.2014.04.018
http://localhost/t...ganizacniJednotka	22310

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