About: Modified MCM-41 as a drug delivery system for acetylsalicylic acid

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The modification of prepared MCM-41 by different groups (amino, chloro and oxo) was studied. Prepared materials were treated by acetylsalicylic acid and hybrid materials were characterized, compared from the point of view of immobilized amount of active substance. The highest amount of acetylsalicylic acid was detected using methyl-tert- butyl ether as a solvent and MCM-41 without modification after 1 h (0.35 g per 1 g of the support) or MCM modified by amino group after 5 h (0.37 g per 1 g of the support) as a support. Using amino modified MCM, the longer treatment by acetylsalicylic acid converged to the equilibrium and after 24 h the immobilized amount was 0.3 g per 1 g. A dissolution in vitro study was carried out, comparing the stability of formed interactions. The slowest dissolution was detected using non-modified MCM-41 and oxo modified material. The modification of prepared MCM-41 by different groups (amino, chloro and oxo) was studied. Prepared materials were treated by acetylsalicylic acid and hybrid materials were characterized, compared from the point of view of immobilized amount of active substance. The highest amount of acetylsalicylic acid was detected using methyl-tert- butyl ether as a solvent and MCM-41 without modification after 1 h (0.35 g per 1 g of the support) or MCM modified by amino group after 5 h (0.37 g per 1 g of the support) as a support. Using amino modified MCM, the longer treatment by acetylsalicylic acid converged to the equilibrium and after 24 h the immobilized amount was 0.3 g per 1 g. A dissolution in vitro study was carried out, comparing the stability of formed interactions. The slowest dissolution was detected using non-modified MCM-41 and oxo modified material. (en)
Title	Modified MCM-41 as a drug delivery system for acetylsalicylic acid Modified MCM-41 as a drug delivery system for acetylsalicylic acid (en)
skos:prefLabel	Modified MCM-41 as a drug delivery system for acetylsalicylic acid Modified MCM-41 as a drug delivery system for acetylsalicylic acid (en)
skos:notation	RIV/60461373:22310/14:43897772!RIV15-MSM-22310___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Machová, Libuše Luštická, Ivana Červený, Libor Paterová, Iva Vyskočilová, Eliška
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	30140
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/14:43897772
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Dissolution; Surface modification; MCM-41; Acetylsalicylic acid (en)
http://linked.open.../riv/klicoveSlovo	Surface modification Acetylsalicylic acid MCM-41 Dissolution
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[AC7710B5207B]
http://linked.open...i/riv/nazevZdroje	Solid State Sciences
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	38
http://linked.open...iv/tvurceVysledku	Červený, Libor Paterová, Iva Vyskočilová, Eliška Luštická, Ivana Machová, Libuše
http://linked.open...ain/vavai/riv/wos	000345154100014
issn	1293-2558
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.solidstatesciences.2014.10.004
http://localhost/t...ganizacniJednotka	22310

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