About: Preparation and characterization of lipid nanoparticles containing lipophilic actives

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to prepare two types of colloidal systems, liposomes and lipid nanoparticles, containing commercially available ceramide VI. Ceramides are the main components of the stratum corneum, the physical and mechanical barrier of the skin. Ceramide supplementation is on approach to the treatment of a disrupted skin in diseases such as atopic dermatitis, ichthyosis, psoriasis and others. Different amounts of cermide VI were loaded into the colloidal nanoparticles. High performance thin layer chromatography was used to confirm the amount of the incorporated ceramide VI. Size and zeta potential of the particles were determined by dynamic light scattering method. The particles were visualized by transmission electron microscopy. Our results suggest that colloidal nanoparticles are suitable drug delivery systems to incorporate ceramide VI. Both, liposomes and lipid nanoparticles, have shown a spherical shpae, an average size below the 100nm and a low polydispersity index. Very good stability was obtained with the particles of 5% loaded ceramide VI. The aim of this study was to prepare two types of colloidal systems, liposomes and lipid nanoparticles, containing commercially available ceramide VI. Ceramides are the main components of the stratum corneum, the physical and mechanical barrier of the skin. Ceramide supplementation is on approach to the treatment of a disrupted skin in diseases such as atopic dermatitis, ichthyosis, psoriasis and others. Different amounts of cermide VI were loaded into the colloidal nanoparticles. High performance thin layer chromatography was used to confirm the amount of the incorporated ceramide VI. Size and zeta potential of the particles were determined by dynamic light scattering method. The particles were visualized by transmission electron microscopy. Our results suggest that colloidal nanoparticles are suitable drug delivery systems to incorporate ceramide VI. Both, liposomes and lipid nanoparticles, have shown a spherical shpae, an average size below the 100nm and a low polydispersity index. Very good stability was obtained with the particles of 5% loaded ceramide VI. (en)
Title	Preparation and characterization of lipid nanoparticles containing lipophilic actives Preparation and characterization of lipid nanoparticles containing lipophilic actives (en)
skos:prefLabel	Preparation and characterization of lipid nanoparticles containing lipophilic actives Preparation and characterization of lipid nanoparticles containing lipophilic actives (en)
skos:notation	RIV/60461373:22310/14:43897693!RIV15-GA0-22310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GA13-23891S), S
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zbytovská, Jarmila
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	38996
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/14:43897693
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lipophilic; lipid nanoparticles (en)
http://linked.open.../riv/klicoveSlovo	lipophilic lipid nanoparticles
http://linked.open...ontrolniKodProRIV	[B8F4F972C518]
http://linked.open...v/mistoKonaniAkce	Tatranské Matliare
http://linked.open...i/riv/mistoVydani	Bratislava
http://linked.open...i/riv/nazevZdroje	Proceedings of the 41st International Conference of Slovak Society of Chemical Engineering
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Štěpánek, František Zbytovská, Jarmila Ulbrich, Pavel Vidlářová, Lucie
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2014-05-26 (xsd:date)
number of pages	6 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Slovak Society of Chemical Engineering
https://schema.org/isbn	978-80-89475-13-1
http://localhost/t...ganizacniJednotka	22310

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