About: 3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene

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About: 3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Metabolism of benzene, an important environmental and industrial carcinogen, produces three electrophilic intermediates, namely, benzene oxide (BO), 1,2- and 1,4-benzoquinone (1,2-BQ and 1,4-BQ). Numerous DNA adducts formed by these metabolites in vitro have been reported in the literature but only one of them was hitherto identified in vivo. In a search for urinary DNA adducts specific LC-ESI-MS methods have been developed for determination in urine of six nucleobase adducts Mice were exposed to benzene vapours at concentrations of 900 and 1800 mg/m3, 6 h/day for 15 consecutive days. The only adduct detected in their urine was DHPA. It was found in 8 out of total 30 urine samples from the high exposure group at concentrations of 352 +/- 146 pg/ml, whereas urines from the low exposure were negative. Conversion of benzene to DHPA was estimated to 2.2 x 10-6 % of the absorbed dose. In conclusion, DHPA is an easily depurinating adduct thus allowing indication of only high recent exposure to benzene, but not long-term damage to DNA in tissues. Metabolism of benzene, an important environmental and industrial carcinogen, produces three electrophilic intermediates, namely, benzene oxide (BO), 1,2- and 1,4-benzoquinone (1,2-BQ and 1,4-BQ). Numerous DNA adducts formed by these metabolites in vitro have been reported in the literature but only one of them was hitherto identified in vivo. In a search for urinary DNA adducts specific LC-ESI-MS methods have been developed for determination in urine of six nucleobase adducts Mice were exposed to benzene vapours at concentrations of 900 and 1800 mg/m3, 6 h/day for 15 consecutive days. The only adduct detected in their urine was DHPA. It was found in 8 out of total 30 urine samples from the high exposure group at concentrations of 352 +/- 146 pg/ml, whereas urines from the low exposure were negative. Conversion of benzene to DHPA was estimated to 2.2 x 10-6 % of the absorbed dose. In conclusion, DHPA is an easily depurinating adduct thus allowing indication of only high recent exposure to benzene, but not long-term damage to DNA in tissues. (en)
Title	3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene 3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene (en)
skos:prefLabel	3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene 3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene (en)
skos:notation	RIV/60461373:22310/13:43891662!RIV14-MSM-22310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B08051), P(LC06070), Z(MSM6046137301)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Krouželka, Jan Králík, Antonín Linhart, Igor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	119832
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/13:43891662
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N3-Adenine adducts; Metabolism; DNA adducts; Benzoquinones; Benzene oxide; Benzene (en)
http://linked.open.../riv/klicoveSlovo	DNA adducts Benzene oxide Benzoquinones N3-Adenine adducts Benzene Metabolism
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E4721A2FAD75]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Toxicology
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New Strategy for Biological Monitoring of Exposure to Mutagens and Carcinogens The structure and synthetic applications of transition metal complexes
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Mikeš, Petr Frantík, Emil Linhart, Igor Mráz, Jaroslav Králík, Antonín Krouželka, Jan Šístek, Václav
http://linked.open...ain/vavai/riv/wos	000318112500016
http://linked.open...n/vavai/riv/zamer	Catalytic processes in chemistry and chemical technology
issn	0260-437X
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jat.2716
http://localhost/t...ganizacniJednotka	22310

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