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Description
  • The paper evaluated the efficiency of a standard cleaning procedure of the process equipment after production of anti hypertensive with the active component Losartan Potassium for different lengths of time between completion of production and the start of the treatment process - so called dirty-hold time. It has been found that the cleaning process is appropriately designed and efficient. The concentration of losartan in swabs from the equipments was in all cases within the limits of acceptance criteria. However, the washing process was in all cases sufficiently effective to meet the eligibility criteria, significant effect of the time of weaning of the contaminated equipment on the efficiency of the washing process was found. At studied dirty hold time horizon (0-4 days) there was a progressive deterioration of the efficiency of the cleaning process. It was found that the influence of the nature of the residual material on the cleaning process has minor effect then the length of the dirty hold time. Laboratory experiments provide comparable results for both wet and dry contamination of the surface.
  • The paper evaluated the efficiency of a standard cleaning procedure of the process equipment after production of anti hypertensive with the active component Losartan Potassium for different lengths of time between completion of production and the start of the treatment process - so called dirty-hold time. It has been found that the cleaning process is appropriately designed and efficient. The concentration of losartan in swabs from the equipments was in all cases within the limits of acceptance criteria. However, the washing process was in all cases sufficiently effective to meet the eligibility criteria, significant effect of the time of weaning of the contaminated equipment on the efficiency of the washing process was found. At studied dirty hold time horizon (0-4 days) there was a progressive deterioration of the efficiency of the cleaning process. It was found that the influence of the nature of the residual material on the cleaning process has minor effect then the length of the dirty hold time. Laboratory experiments provide comparable results for both wet and dry contamination of the surface. (en)
Title
  • Dirty-Hold Time Effect on the Cleaning Process Efficiency
  • Dirty-Hold Time Effect on the Cleaning Process Efficiency (en)
skos:prefLabel
  • Dirty-Hold Time Effect on the Cleaning Process Efficiency
  • Dirty-Hold Time Effect on the Cleaning Process Efficiency (en)
skos:notation
  • RIV/60461373:22310/12:43894830!RIV13-MSM-22310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6046137301)
http://linked.open...iv/cisloPeriodika
  • September
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 131439
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22310/12:43894830
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Wet swabs; Dirty hold-time; Cleaning process (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [04A324E1061E]
http://linked.open...i/riv/nazevZdroje
  • Procedia Engineering
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 42
http://linked.open...iv/tvurceVysledku
  • Zámostný, Petr
  • Patera, Jan
  • Bělohlav, Zdeněk
  • Štípková, Gabriela
http://linked.open...n/vavai/riv/zamer
issn
  • 1877-7058
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.proeng.2012.07.434
http://localhost/t...ganizacniJednotka
  • 22310
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