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Description
  • In vitro cultured mammalian cells are able to sense micro- and nanotopographical features of their substratum, resulting in contact guidance of the cells along topographical features, altered motility, proliferation and differentiation. We here used embossed polyester films with nanogrooves to study the dynamics of cell spreading and alignment of chinese hamster ovary (CHO) cells and cells of a rat myogenic cell line. Our results suggest that the response of the cells studied is driven by initial cytoplasmic protrusions, which emerge along the nanogrooves and pull the cells along the direction of the nanogrooves.
  • In vitro cultured mammalian cells are able to sense micro- and nanotopographical features of their substratum, resulting in contact guidance of the cells along topographical features, altered motility, proliferation and differentiation. We here used embossed polyester films with nanogrooves to study the dynamics of cell spreading and alignment of chinese hamster ovary (CHO) cells and cells of a rat myogenic cell line. Our results suggest that the response of the cells studied is driven by initial cytoplasmic protrusions, which emerge along the nanogrooves and pull the cells along the direction of the nanogrooves. (en)
Title
  • Dynamics of the alignment of mammalian cells on a nano-structured polymer surface
  • Dynamics of the alignment of mammalian cells on a nano-structured polymer surface (en)
skos:prefLabel
  • Dynamics of the alignment of mammalian cells on a nano-structured polymer surface
  • Dynamics of the alignment of mammalian cells on a nano-structured polymer surface (en)
skos:notation
  • RIV/60461373:22310/10:00023060!RIV11-MSM-22310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 1
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http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
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http://linked.open...titaPredkladatele
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  • 255577
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22310/10:00023060
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Cell attachment; cell orientation; embossing; filopodia; nanotopography (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [5126E0FACF07]
http://linked.open...i/riv/nazevZdroje
  • Macromolecular Symposia
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 296
http://linked.open...iv/tvurceVysledku
  • Heitz, J.
  • Siegel, Jakub
  • Peterbauer, T.
  • Yakunin, S.
issn
  • 1521-3900
number of pages
http://localhost/t...ganizacniJednotka
  • 22310
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