About: SYNTHESIS AND PROPERTIES OF NOVEL BIOLOGICALLY INTERESTING POLYCYCLIC 1,3,4-OXADIAZOLES CONTAINING ACRIDINE/ACRIDONE MOIETIES

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: SYNTHESIS AND PROPERTIES OF NOVEL BIOLOGICALLY INTERESTING POLYCYCLIC 1,3,4-OXADIAZOLES CONTAINING ACRIDINE/ACRIDONE MOIETIES Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A series of polycyclic 1,3,4-oxadiazoles bearing acridine and acridone pharmacophores were synthesized as potential noncovalent DNA-binding and antitumor agents. The synthesis of oxadiazoles with acridone moiety was performed exploring oxidative cyclization of corresponding aldimines via bromine and the acridine derivatives by cyclization of acylthiosemicarbazides with mercuric oxide. The spectroscopic properties of the compounds in the case of acridonoxadiazoles showed an efficient binding activity to DNA (K = 5.3-9.2 x 10(4) M-1), whereas the acridine analogues are suitable as biomarkers. The structure of compounds were characterized by spectral methods (UV-vis, IR, H-1, C-13, and 2D NMR) and quantum-chemical calculations (DFT, ZINDO). A series of polycyclic 1,3,4-oxadiazoles bearing acridine and acridone pharmacophores were synthesized as potential noncovalent DNA-binding and antitumor agents. The synthesis of oxadiazoles with acridone moiety was performed exploring oxidative cyclization of corresponding aldimines via bromine and the acridine derivatives by cyclization of acylthiosemicarbazides with mercuric oxide. The spectroscopic properties of the compounds in the case of acridonoxadiazoles showed an efficient binding activity to DNA (K = 5.3-9.2 x 10(4) M-1), whereas the acridine analogues are suitable as biomarkers. The structure of compounds were characterized by spectral methods (UV-vis, IR, H-1, C-13, and 2D NMR) and quantum-chemical calculations (DFT, ZINDO). (en)
Title	SYNTHESIS AND PROPERTIES OF NOVEL BIOLOGICALLY INTERESTING POLYCYCLIC 1,3,4-OXADIAZOLES CONTAINING ACRIDINE/ACRIDONE MOIETIES SYNTHESIS AND PROPERTIES OF NOVEL BIOLOGICALLY INTERESTING POLYCYCLIC 1,3,4-OXADIAZOLES CONTAINING ACRIDINE/ACRIDONE MOIETIES (en)
skos:prefLabel	SYNTHESIS AND PROPERTIES OF NOVEL BIOLOGICALLY INTERESTING POLYCYCLIC 1,3,4-OXADIAZOLES CONTAINING ACRIDINE/ACRIDONE MOIETIES SYNTHESIS AND PROPERTIES OF NOVEL BIOLOGICALLY INTERESTING POLYCYCLIC 1,3,4-OXADIAZOLES CONTAINING ACRIDINE/ACRIDONE MOIETIES (en)
skos:notation	RIV/60461373:22310/09:00021772!RIV10-MSM-22310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 223100001)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Böhm, Stanislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	345079
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/09:00021772
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Acridine/Acridone Oxadiazole; Structure Study; DNA Binding Property; Theoretical Calculation (DFT, ZINDO) (en)
http://linked.open.../riv/klicoveSlovo	Acridine/Acridone Oxadiazole DNA Binding Property Structure Study Theoretical Calculation (DFT ZINDO)
http://linked.open...odStatuVydavatele	JP - Japonsko
http://linked.open...ontrolniKodProRIV	[68EB60BD77EE]
http://linked.open...i/riv/nazevZdroje	Heterocycles
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	77
http://linked.open...iv/tvurceVysledku	Böhm, Stanislav Imrich, Jan Danihel, Ivan Kristián, Pavol Sabolová, Danica Klika, Karel D Kožurková, Maria Frohlichová, Zdenka Tomasčíková, Jana
http://linked.open...ain/vavai/riv/wos	000264490200035
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223100001
issn	0385-5414
number of pages	17 (xsd:int)
http://localhost/t...ganizacniJednotka	22310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software