About: Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring

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About: Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Methamphetamine is a commonly abused psychostimulant that causes addiction and is often abused by pregnant women. Acute or chronic administration of methamphetamine elevates the levels of the extracellular monoamine neurotransmitters, such as dopamine. The aim of the present study was to show whether prenatal exposure to methamphetamine (5 mg/kg, entire gestation) or saline in Wistar rats induces changes in dopamine levels and its metabolites in the nucleus accumbens, and in behavior (locomotor activity, rearing, and immobility) after the administration of a challenge dose of methamphetamine (1 mg/kg) or saline in male offspring. We found that adult offspring prenatally exposed to methamphetamine had higher basal levels of dopamine (about 288%), dihydroxyphenylacetic acid (about 67%) and homovanillic acid (about 74%) in nucleus accumbens. An increased basal level of dopamine corresponds to lower basal immobility in offspring prenatally exposed to methamphetamine. The acute injection of methamphet Methamphetamine is a commonly abused psychostimulant that causes addiction and is often abused by pregnant women. Acute or chronic administration of methamphetamine elevates the levels of the extracellular monoamine neurotransmitters, such as dopamine. The aim of the present study was to show whether prenatal exposure to methamphetamine (5 mg/kg, entire gestation) or saline in Wistar rats induces changes in dopamine levels and its metabolites in the nucleus accumbens, and in behavior (locomotor activity, rearing, and immobility) after the administration of a challenge dose of methamphetamine (1 mg/kg) or saline in male offspring. We found that adult offspring prenatally exposed to methamphetamine had higher basal levels of dopamine (about 288%), dihydroxyphenylacetic acid (about 67%) and homovanillic acid (about 74%) in nucleus accumbens. An increased basal level of dopamine corresponds to lower basal immobility in offspring prenatally exposed to methamphetamine. The acute injection of methamphet (en)
Title	Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring (en)
skos:prefLabel	Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring (en)
skos:notation	RIV/60461373:22310/09:00021559!RIV10-MSM-22310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0517), P(GA305/09/0126), Z(MSM6046137301)
http://linked.open...iv/cisloPeriodika	27
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kačer, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	335668
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/09:00021559
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Methamphetamine; Prenatal exposure; Dopamine (en)
http://linked.open.../riv/klicoveSlovo	Prenatal exposure Methamphetamine Dopamine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D1577EFF982C]
http://linked.open...i/riv/nazevZdroje	International Journal of Developmental Neuroscience
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) Does prenatal methamphetamine exposure induce cross-sensitization to drugs in adult male and female rats?
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Kačer, Petr Syslová, Kamila Bubenikova-Valesova, Vera Hruba, Lenka Janovsky, Martin Rambousek, Lukas Schutova, Barbora Slamberova, Romana
http://linked.open...ain/vavai/riv/wos	000269816300003
http://linked.open...n/vavai/riv/zamer	Catalytic processes in chemistry and chemical technology
issn	0736-5748
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	22310

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