About: Synthesis, Structure, and Cholinergic Effect of Novel Neuroprotective Compounds Bearing the Tacrine Pharmacophore

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About: Synthesis, Structure, and Cholinergic Effect of Novel Neuroprotective Compounds Bearing the Tacrine Pharmacophore Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Novel tacrine congeners with side ligands suitable for optimal interaction with the peripheral and catalytic sites of acetyl- and butyrylcholinesterase (AChE and BuChE) have been synthesized using either 9-isothiocyanato-1,2,3,4-tetrahyhroacridine or 9-chloro-1,2,3,4-tetrahydroacridi- ne which represent convenient synthons by reaction with various substituted amines. The synthesized compounds were tested for their inhibition of AChE and BuChE whereby a morpholine and a furfuryl derivative were found to be the most potent AChE and BuChE inhibitors, respectively, with the latter compound comparable in activity to tacrine. Novel tacrine congeners with side ligands suitable for optimal interaction with the peripheral and catalytic sites of acetyl- and butyrylcholinesterase (AChE and BuChE) have been synthesized using either 9-isothiocyanato-1,2,3,4-tetrahyhroacridine or 9-chloro-1,2,3,4-tetrahydroacridi- ne which represent convenient synthons by reaction with various substituted amines. The synthesized compounds were tested for their inhibition of AChE and BuChE whereby a morpholine and a furfuryl derivative were found to be the most potent AChE and BuChE inhibitors, respectively, with the latter compound comparable in activity to tacrine. (en)
Title	Synthesis, Structure, and Cholinergic Effect of Novel Neuroprotective Compounds Bearing the Tacrine Pharmacophore Synthesis, Structure, and Cholinergic Effect of Novel Neuroprotective Compounds Bearing the Tacrine Pharmacophore (en)
skos:prefLabel	Synthesis, Structure, and Cholinergic Effect of Novel Neuroprotective Compounds Bearing the Tacrine Pharmacophore Synthesis, Structure, and Cholinergic Effect of Novel Neuroprotective Compounds Bearing the Tacrine Pharmacophore (en)
skos:notation	RIV/60461373:22310/08:00021410!RIV10-MSM-22310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000604), Z(MSM6046137301)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Böhm, Stanislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	398816
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/08:00021410
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Tacrine Pharmacophore; synthesis (en)
http://linked.open.../riv/klicoveSlovo	Tacrine Pharmacophore synthesis
http://linked.open...odStatuVydavatele	JP - Japonsko
http://linked.open...ontrolniKodProRIV	[2A3BCB98AD2B]
http://linked.open...i/riv/nazevZdroje	Heterocycles
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Böhm, Stanislav Jun, Daniel Kuca, Kamil Kristian, Pavol Hamulšaková, Slavka Imrich, Ján Danihel, Ivan Klika, Karel D.
http://linked.open...ain/vavai/riv/wos	000262427000032
http://linked.open...n/vavai/riv/zamer	Catalytic processes in chemistry and chemical technology Informační zabezpečení krizového managementu pro oblast zdravotnictví
issn	0385-5414
number of pages	17 (xsd:int)
http://localhost/t...ganizacniJednotka	22310

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