About: Synthesis and Evaluation of Long-Acting d-Penicillamine Derivatives     Goto   Sponge   NotDistinct   Permalink

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Description
  • Toto studium rozšiřuje možnost použití lathyrogenů, beta-aminopropionitrilu a penicilaminu z denního nebo lokálního podávání na dlouhopůsobící činidlo. Toho bylo dosaženo převedením hydrofilního léku na lipofilní deriváty. Syntéza funkčních derivátů DPA spočívá v esterifikaci s methyl-, hexyl- a benzylalkoholem v přítomnosti thyonyl-chloridu. (cs)
  • This study extends the use of two lathyrogens, beta-aminopropionitrile and penicillamine from daily systematic or local-topical administration to long time acting agents. This was achieved by converting the hydrophilic drugs into lipophilic derivatives. The synthesis of functional derivatives of DPA consisted in esterification with methyl-, hexyl- and benzyl alcohols in the presence of thionyl chloride.
  • This study extends the use of two lathyrogens, beta-aminopropionitrile and penicillamine from daily systematic or local-topical administration to long time acting agents. This was achieved by converting the hydrophilic drugs into lipophilic derivatives. The synthesis of functional derivatives of DPA consisted in esterification with methyl-, hexyl- and benzyl alcohols in the presence of thionyl chloride. (en)
Title
  • Synthesis and Evaluation of Long-Acting d-Penicillamine Derivatives
  • Syntéza a studium dlouhopůsobící deriváty d-penicilaminu (cs)
  • Synthesis and Evaluation of Long-Acting d-Penicillamine Derivatives (en)
skos:prefLabel
  • Synthesis and Evaluation of Long-Acting d-Penicillamine Derivatives
  • Syntéza a studium dlouhopůsobící deriváty d-penicilaminu (cs)
  • Synthesis and Evaluation of Long-Acting d-Penicillamine Derivatives (en)
skos:notation
  • RIV/60461373:22310/05:00013635!RIV06-MSM-22310___
http://linked.open.../vavai/riv/strany
  • 242-250
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6046137301)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 545706
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22310/05:00013635
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Collagen as Scafold; Collagen Cross-Links; D-Penicillamine-Esters; Fibrosis, Lathyrogens; Wound Breaking Strength (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [7662DB61DF92]
http://linked.open...i/riv/nazevZdroje
  • Connective Tissue Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 46
http://linked.open...iv/tvurceVysledku
  • Liška, František
  • Šilhánková, Alexandra
  • Kielar, F.
  • Bregel, Klaus
  • Chvapil, Miloš
http://linked.open...n/vavai/riv/zamer
issn
  • 0300-8207
number of pages
http://localhost/t...ganizacniJednotka
  • 22310
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