About: Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Syntéza tří monopyridiniových oximů a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervovými jedy (cs) There were synthesized three potential reactivators of nerve agents-inhibited acetylcholinesterase: 2-[(hydroxyimino)phenylmethyl]-1-methylpyridinium iodide 3a, 2-[(hydroxyimino)pyridin-2-ylmethyl]-1-methylpyridinium iodide 3b and 2-[(1-hydroxyimino) ethyl]-1-methylpyridinium iodide 3c. Their reactivation potency was examined using standard in vitro reactivation test. As the source of acetylcholinesterase was used rat brain homogenate. Their reactivation potency was compared with currently used acetylcholinesterase reactivator - 2-PAM (pralidoxime) 4. All tested reactivator were worse acetylcholinesterase reactivators in regard to 2-PAM. In this paper we have also tested reactivation potency of the oxime 2-PAM against inhibition acetylcholinesterase by sarin, cyclosarin, VX and tabun. Satisfactory results are shown only by reactivation sarin- and VX-inhibited acetylcholinesterase. There were synthesized three potential reactivators of nerve agents-inhibited acetylcholinesterase: 2-[(hydroxyimino)phenylmethyl]-1-methylpyridinium iodide 3a, 2-[(hydroxyimino)pyridin-2-ylmethyl]-1-methylpyridinium iodide 3b and 2-[(1-hydroxyimino) ethyl]-1-methylpyridinium iodide 3c. Their reactivation potency was examined using standard in vitro reactivation test. As the source of acetylcholinesterase was used rat brain homogenate. Their reactivation potency was compared with currently used acetylcholinesterase reactivator - 2-PAM (pralidoxime) 4. All tested reactivator were worse acetylcholinesterase reactivators in regard to 2-PAM. In this paper we have also tested reactivation potency of the oxime 2-PAM against inhibition acetylcholinesterase by sarin, cyclosarin, VX and tabun. Satisfactory results are shown only by reactivation sarin- and VX-inhibited acetylcholinesterase. (en)
Title	Syntéza tří monopyridiniových oximů a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervovými jedy (cs) Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents (en)
skos:prefLabel	Syntéza tří monopyridiniových oximů a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervovými jedy (cs) Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents (en)
skos:notation	RIV/60461373:22310/04:00020154!RIV09-GA0-22310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA203/01/1093), P(ONVLAJEP20031)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Liška, František Pícha, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	589370
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/04:00020154
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	VX; reactivation; acetylcholinesterase; oximes; sarin; tabun; cyclosarin (en)
http://linked.open.../riv/klicoveSlovo	cyclosarin oximes VX acetylcholinesterase reactivation sarin tabun
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[DA1CCC33EB84]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators The effect of electron distribution on the oxime reactivity towards esters
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Cabal, Jiří Liška, František Pícha, Jan Kuča, Kamil.
issn	1214-021X
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	22310

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