About: Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte aging in vitro

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About: Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte aging in vitro Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Oocyte aging is the complex of processes that occur when matured in vitro oocytes are exposed, after reaching the metaphase II stage further in the vitro culture. Aged oocytes remaining at the metaphase II stage, underwent spontaneous parthenogenetic activation, or cellular death, through apoptosis (fragmentation) or lysis. The key factor in apoptotic pathway regulation is c-Jun-terminal kinase (JNK), stress kinase from the MAPK kinase family. To investigate the effect of JNK inhibition on porcine oocytes aging, cleavage rate and embryonic development after parthenogenetic activation, DNA fragmentation, and pro-apoptotic factor Bax expression, we cultured in vitro matured oocytes for another 1 to 4 days in the presence of a JNK inhibitor. The inhibition of JNK significantly protected oocytes from the fragmentation (0.0 % of fragmented oocytes under JNK inhibition vs. 13.4% of fragmented oocytes in the control group, second day of aging) and increased the percentage of parthenogenetically activated Oocyte aging is the complex of processes that occur when matured in vitro oocytes are exposed, after reaching the metaphase II stage further in the vitro culture. Aged oocytes remaining at the metaphase II stage, underwent spontaneous parthenogenetic activation, or cellular death, through apoptosis (fragmentation) or lysis. The key factor in apoptotic pathway regulation is c-Jun-terminal kinase (JNK), stress kinase from the MAPK kinase family. To investigate the effect of JNK inhibition on porcine oocytes aging, cleavage rate and embryonic development after parthenogenetic activation, DNA fragmentation, and pro-apoptotic factor Bax expression, we cultured in vitro matured oocytes for another 1 to 4 days in the presence of a JNK inhibitor. The inhibition of JNK significantly protected oocytes from the fragmentation (0.0 % of fragmented oocytes under JNK inhibition vs. 13.4% of fragmented oocytes in the control group, second day of aging) and increased the percentage of parthenogenetically activated (en)
Title	Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte aging in vitro Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte aging in vitro (en)
skos:prefLabel	Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte aging in vitro Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte aging in vitro (en)
skos:notation	RIV/60460709:41210/13:61524!RIV14-MSM-41210___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Nevoral, Jan Chmelíková, Eva Tůmová, Lenka Krejčová, Tereza Dörflerová (Čtrnáctá), Andrea Sedmíková, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Česká zemědělská univerzita v Praze / Fakulta agrobiologie, potravinových a přírodních zdrojů
http://linked.open...dnocenehoVysledku	80209
http://linked.open...ai/riv/idVysledku	RIV/60460709:41210/13:61524
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MAPK, fragmentation, apoptosis, Bax, pig (en)
http://linked.open.../riv/klicoveSlovo	MAPK apoptosis pig fragmentation Bax
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[C420744613F1]
http://linked.open...i/riv/nazevZdroje	Czech Journal of Animal Science
http://linked.open...in/vavai/riv/obor	GI
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Petr, Jaroslav Novotná, B. Tůmová, Lenka Chmelíková, Eva Sedmíková, Markéta Dörflerová (Čtrnáctá), Andrea Krejčová, Tereza Nevoral, Jan
http://linked.open...ain/vavai/riv/wos	000328563000001
issn	1212-1819
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	41210

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