About: Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Quinones are compounds frequently contained in medicinal plants used for the treatment of inflammatory diseases. Therefore, the impact of plant-derived quinones on the arachidonic acid metabolic pathway is worthy of investigation. In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B-4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. The benzoquinones primin (3) and thymohydroquinone (4) (IC50 = 4.0 and 4.1 mu M, respectively) showed activity comparable with the reference inhibitor zileuton (IC50 = 4.1 mu M). Moderate activity was observed for the benzoquinone thymoquinone (2) (IC50 = 18.2 mu M) and the naphthoquinone shikonin (1) (IC50 = 24.3 mu M). The anthraquinone emodin and the naphthoquinone plumbagin (5) displayed only weak activities (IC50 > 50 mu M). The binding modes of the active compounds were further evaluated in silico by molecular docking to the human 5-LOX crys Quinones are compounds frequently contained in medicinal plants used for the treatment of inflammatory diseases. Therefore, the impact of plant-derived quinones on the arachidonic acid metabolic pathway is worthy of investigation. In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B-4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. The benzoquinones primin (3) and thymohydroquinone (4) (IC50 = 4.0 and 4.1 mu M, respectively) showed activity comparable with the reference inhibitor zileuton (IC50 = 4.1 mu M). Moderate activity was observed for the benzoquinone thymoquinone (2) (IC50 = 18.2 mu M) and the naphthoquinone shikonin (1) (IC50 = 24.3 mu M). The anthraquinone emodin and the naphthoquinone plumbagin (5) displayed only weak activities (IC50 > 50 mu M). The binding modes of the active compounds were further evaluated in silico by molecular docking to the human 5-LOX crys (en)
Title	Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones (en)
skos:prefLabel	Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones (en)
skos:notation	RIV/60460709:41210/13:60053!RIV14-MSM-41210___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GP525/09/P528), P(MEB061112), S, Z(AV0Z50380511)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Malík, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Česká zemědělská univerzita v Praze / Fakulta agrobiologie, potravinových a přírodních zdrojů
http://linked.open...dnocenehoVysledku	80210
http://linked.open...ai/riv/idVysledku	RIV/60460709:41210/13:60053
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	5-Lipoxygenase, Anti-inflammatory activity, Dual COX/LOX inhibition, Natural compounds, Molecular docking (en)
http://linked.open.../riv/klicoveSlovo	5-Lipoxygenase Dual COX/LOX inhibition Molecular docking Anti-inflammatory activity Natural compounds
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F39A27872A41]
http://linked.open...i/riv/nazevZdroje	Natural Product Communications
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Discovery and Analysis of New Redox-Based Inhibitors for Cyclooxygenase and Lipoxygenase Anti-inflammatory activity of plant quinones
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Dvořáková, Marcela Kokoška, Ladislav Malík, Jan Maršík, Petr Vaněk, Tomáš Landa, Přemysl Přibylová, Marie Kutil, Zsófia Schuster, Daniela Temml, Veronika Bauer, Rudolf Widowitz, Ute
http://linked.open...ain/vavai/riv/wos	000314617200027
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy
issn	1934-578X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	41210

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