About: Nitric Oxide-Donor SNAP Induces Xenopus Eggs Activation

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nitric oxide (NO) is identified as a signaling molecule involved in many cellular or physiological functions including meiotic maturation and parthenogenetic activation of mammalian oocytes. We observed that nitric oxide donor SNAP was potent to induce parthenogenetic activation in Xenopus eggs. NO-scavenger CPTIO impaired the effects of SNAP, providing evidence for the effects of the latter to be specific upon NO release. In Xenopus eggs, SNAP treatment induced pigment rearrangement, pronucleus formation and exocytosis of cortical granules. At a biochemical level, SNAP exposure lead to MAPK and Rsk inactivation within 30 minutes whereas MPF remained active, in contrast to calcium ionophore control where MPF activity dropped rapidly. MAPK inactivation could be correlated to pronuclear envelope reformation observed. In SNAP-treated eggs, a strong increase in intracellular calcium level was observed. NO effects were impaired in calcium-free or calcium limited medium, suggesting that that parthenogeneti Nitric oxide (NO) is identified as a signaling molecule involved in many cellular or physiological functions including meiotic maturation and parthenogenetic activation of mammalian oocytes. We observed that nitric oxide donor SNAP was potent to induce parthenogenetic activation in Xenopus eggs. NO-scavenger CPTIO impaired the effects of SNAP, providing evidence for the effects of the latter to be specific upon NO release. In Xenopus eggs, SNAP treatment induced pigment rearrangement, pronucleus formation and exocytosis of cortical granules. At a biochemical level, SNAP exposure lead to MAPK and Rsk inactivation within 30 minutes whereas MPF remained active, in contrast to calcium ionophore control where MPF activity dropped rapidly. MAPK inactivation could be correlated to pronuclear envelope reformation observed. In SNAP-treated eggs, a strong increase in intracellular calcium level was observed. NO effects were impaired in calcium-free or calcium limited medium, suggesting that that parthenogeneti (en)
Title	Nitric Oxide-Donor SNAP Induces Xenopus Eggs Activation Nitric Oxide-Donor SNAP Induces Xenopus Eggs Activation (en)
skos:prefLabel	Nitric Oxide-Donor SNAP Induces Xenopus Eggs Activation Nitric Oxide-Donor SNAP Induces Xenopus Eggs Activation (en)
skos:notation	RIV/60460709:41210/12:54912!RIV14-GA0-41210___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GD523/08/H064), Z(MSM6046070901), Z(MZE0002701404), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Tichovská, Hana Sedmíková, Markéta Melicharová, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Česká zemědělská univerzita v Praze / Fakulta agrobiologie, potravinových a přírodních zdrojů
http://linked.open...dnocenehoVysledku	154247
http://linked.open...ai/riv/idVysledku	RIV/60460709:41210/12:54912
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Nitric Oxide, Xenopus laevis, Parthenogenetic Activation, SNAP, CPTIO (en)
http://linked.open.../riv/klicoveSlovo	Xenopus laevis CPTIO Nitric Oxide Parthenogenetic Activation SNAP
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6BA23610ABBD]
http://linked.open...i/riv/nazevZdroje	PLoS One
http://linked.open...in/vavai/riv/obor	GG
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Biotechnologies of mammalian gametes
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Petr, Jaroslav Tichovská, Hana Sedmíková, Markéta Bodart, Jean-Francois Beaujois, Rémy Cailliau-Maggio, Katia Ješeta, M. Lescuyer-Rousseau, Arlette Marin, Matthieu Martoriati, Alain Melicharová, Petra
http://linked.open...ain/vavai/riv/wos	000306687700096
http://linked.open...n/vavai/riv/zamer	Setrvalé zemědělství, kvalita zemědělské produkce, krajinné a přírodní zdroje. Udržitelný rozvoj chovu hospodářských zvířat v evropském modelu multifunkčního zemědělství Animal disease research, prevention and food chain protection
issn	1932-6203
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	41210

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