About: Discard volume necessary for elimination of heparin flush effect on thromboelastography

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Heparin is commonly used to prevent obstruction of indwelling arterial catheters with blood clots. It is known to affect the outcomes of analysis of coagulation parameters with thromboelastography (TEG); therefore, it has been recommended to neutralize its effect with heparinase. However, heparinase may also neutralize the effect of low molecular weight heparin and endogenous heparinoids present in critically ill patients. The aim of this study was to evaluate the minimal discard blood volume needed to eliminate the effect of heparin flush on TEG parameters without the use of heparinase. Coagulation parameters were evaluated with kaolin-activated TEG. We found an increase in coagulation (reflecting the heparin elimination)with the increasing discard volume between 1 and 4 ml. This was obvious from an increase in a angle and maximal amplitude of the measured clot and a decrease in R and time to maximal amplitude of the measured clot (P<0.001). Heparin is commonly used to prevent obstruction of indwelling arterial catheters with blood clots. It is known to affect the outcomes of analysis of coagulation parameters with thromboelastography (TEG); therefore, it has been recommended to neutralize its effect with heparinase. However, heparinase may also neutralize the effect of low molecular weight heparin and endogenous heparinoids present in critically ill patients. The aim of this study was to evaluate the minimal discard blood volume needed to eliminate the effect of heparin flush on TEG parameters without the use of heparinase. Coagulation parameters were evaluated with kaolin-activated TEG. We found an increase in coagulation (reflecting the heparin elimination)with the increasing discard volume between 1 and 4 ml. This was obvious from an increase in a angle and maximal amplitude of the measured clot and a decrease in R and time to maximal amplitude of the measured clot (P<0.001). (en)
Title	Discard volume necessary for elimination of heparin flush effect on thromboelastography Discard volume necessary for elimination of heparin flush effect on thromboelastography (en)
skos:prefLabel	Discard volume necessary for elimination of heparin flush effect on thromboelastography Discard volume necessary for elimination of heparin flush effect on thromboelastography (en)
skos:notation	RIV/60460709:41110/10:47958!RIV11-MSM-41110___
http://linked.open...avai/riv/aktivita	S V
http://linked.open...avai/riv/aktivity	S, V
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pacáková, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Česká zemědělská univerzita v Praze / Provozně ekonomická fakulta
http://linked.open...dnocenehoVysledku	254564
http://linked.open...ai/riv/idVysledku	RIV/60460709:41110/10:47958
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	arterial blood sampling, coagulation, discard volume, heparin flush, kaolin-activated, thromboelastography (en)
http://linked.open.../riv/klicoveSlovo	thromboelastography coagulation arterial blood sampling discard volume heparin flush kaolin-activated
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E368CC8F823D]
http://linked.open...i/riv/nazevZdroje	Blood Coagulation & Fibrinolysis
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Pacáková, Zuzana Cvachovec, Karel Durila, Miroslav Kalinčík, Tomáš
http://linked.open...ain/vavai/riv/wos	000274513600017
issn	0957-5235
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	41110

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