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| Description
| - Francisella tularensis, a facultative intracellular Gram-negative bacterium, causes the illness tularemia. The infection of mice with live vaccine strain is considered to be a model of human tularemia. E tularensis infects predominantly such phagocytic cells as macrophages or neutrophils, but it also infects non-phagocytic hepatocytes, epithelial cells, and murine and human B cell lines. Based on work with the murine tularemia model, we report here that F. tularensis LVS infects peritoneal CD19(+) cells - exclusively B-la cells early after intraperitoneal infection in vivo. The peritoneal and consequently spleen CD19+ cells are activated by the F. tularensis LVS infection to express the activation markers from MHC class II, CD25, CD54, CD69, and the co-stimulatory molecules CD80 and CD86. As early as 12 h post-infection, the peritoneal CD19(+) cells produce IFN-gamma, IL-1 beta, IL-4, IL-6, IL-12, IL-17, IL-23, and THE-alpha. The spleen CD19(+) cells respond to infection with some delay. Moreover, the E tularensis infected A20 B cell line activates CD3(+) spleen cells isolated from naive mice. Thus, the data presented here suggest that B cells have all the attributes to actively participate in the induction and regulation of the adaptive immune response during early stages of E tularensis infection.
- Francisella tularensis, a facultative intracellular Gram-negative bacterium, causes the illness tularemia. The infection of mice with live vaccine strain is considered to be a model of human tularemia. E tularensis infects predominantly such phagocytic cells as macrophages or neutrophils, but it also infects non-phagocytic hepatocytes, epithelial cells, and murine and human B cell lines. Based on work with the murine tularemia model, we report here that F. tularensis LVS infects peritoneal CD19(+) cells - exclusively B-la cells early after intraperitoneal infection in vivo. The peritoneal and consequently spleen CD19+ cells are activated by the F. tularensis LVS infection to express the activation markers from MHC class II, CD25, CD54, CD69, and the co-stimulatory molecules CD80 and CD86. As early as 12 h post-infection, the peritoneal CD19(+) cells produce IFN-gamma, IL-1 beta, IL-4, IL-6, IL-12, IL-17, IL-23, and THE-alpha. The spleen CD19(+) cells respond to infection with some delay. Moreover, the E tularensis infected A20 B cell line activates CD3(+) spleen cells isolated from naive mice. Thus, the data presented here suggest that B cells have all the attributes to actively participate in the induction and regulation of the adaptive immune response during early stages of E tularensis infection. (en)
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| Title
| - B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection
- B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection (en)
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| skos:prefLabel
| - B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection
- B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection (en)
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| skos:notation
| - RIV/60162694:G44__/14:43875161!RIV15-MO0-G44_____
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/14:43875161
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Antigen-presenting function; Activating markers; Cytokines; B cells; F. tularensis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kročová, Zuzana
- Zárybnická, Lenka
- Šinkorová, Zuzana
- Kubelková, Klára
- Plzáková, Lenka
- Macela, Aleš (Prof. Emerit.)
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1016/j.micpath.2014.08.009
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| http://localhost/t...ganizacniJednotka
| |
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