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  • Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitored both enzymatic and non-enzymatic antioxidants - glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enzymatic parameters with the increasing taurine supplementation.
  • Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitored both enzymatic and non-enzymatic antioxidants - glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enzymatic parameters with the increasing taurine supplementation. (en)
Title
  • Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach
  • Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach (en)
skos:prefLabel
  • Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach
  • Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach (en)
skos:notation
  • RIV/60162694:G44__/14:43875120!RIV15-MO0-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(EE2.3.30.0017), S, V
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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  • 22699
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  • RIV/60162694:G44__/14:43875120
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Wistar rats; Metallothionein; Glutathione; Oxidative stress; Thiol antioxidant; Taurine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [D9B032D1665D]
http://linked.open...i/riv/nazevZdroje
  • Journal of Applied Biomedicine - print
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 12
http://linked.open...iv/tvurceVysledku
  • Adam, Vojtěch
  • Beklová, Miroslava
  • Babula, Petr
  • Kizek, René
  • Pohanka, Miroslav
  • Sochor, Jiří
  • Zeman, Ladislav
  • Zitka, Ondřej
  • Mareš, Petr
  • Cernei, Natalia
  • Bezděková, Andrea
  • Ruttkay-Nedecky, Branislav
  • Lukešová, Kateřina
  • Nejdl, Llukáš
http://linked.open...ain/vavai/riv/wos
  • 000334441900005
issn
  • 1214-021X
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.jab.2013.01.002
http://localhost/t...ganizacniJednotka
  • G44
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