About: Serving the new masters - dendritic cells as hosts for stealth intracellular bacteria

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1111/cmi.12160/pdf
Description	Dendritic cells (DCs) serve as the primers of adaptive immunity, which is indispensable for the control of the majority of infections. Interestingly, some pathogenic intracellular bacteria can subvert DC function and gain the advantage of an ineffective host immune reaction. This scenario appears to be the case particularly with so-called stealth pathogens, which are the causative agents of several under-diagnosed chronic diseases. However, there is no consensus how less explored stealth bacteria like Coxiella, Brucella and Francisella crosstalk with DCs. Therefore, the aim of this review was to explore the issue and to summarise the current knowledge regarding the interaction of above mentioned pathogens with DCs as crucial hosts from an infection strategy view. Evidence indicates that infected DCs are not sufficiently activated, do not undergo maturation and do not produce expected proinflammatory cytokines. In some cases, the infected DCs even display immunosuppressive behaviour that may be directly linked to the induction of tolerogenicity favouring pathogen survival and persistence. Dendritic cells (DCs) serve as the primers of adaptive immunity, which is indispensable for the control of the majority of infections. Interestingly, some pathogenic intracellular bacteria can subvert DC function and gain the advantage of an ineffective host immune reaction. This scenario appears to be the case particularly with so-called stealth pathogens, which are the causative agents of several under-diagnosed chronic diseases. However, there is no consensus how less explored stealth bacteria like Coxiella, Brucella and Francisella crosstalk with DCs. Therefore, the aim of this review was to explore the issue and to summarise the current knowledge regarding the interaction of above mentioned pathogens with DCs as crucial hosts from an infection strategy view. Evidence indicates that infected DCs are not sufficiently activated, do not undergo maturation and do not produce expected proinflammatory cytokines. In some cases, the infected DCs even display immunosuppressive behaviour that may be directly linked to the induction of tolerogenicity favouring pathogen survival and persistence. (en)
Title	Serving the new masters - dendritic cells as hosts for stealth intracellular bacteria Serving the new masters - dendritic cells as hosts for stealth intracellular bacteria (en)
skos:prefLabel	Serving the new masters - dendritic cells as hosts for stealth intracellular bacteria Serving the new masters - dendritic cells as hosts for stealth intracellular bacteria (en)
skos:notation	RIV/60162694:G44__/13:43874920!RIV14-MO0-G44_____
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Řehulka, Pavel Stulík, Jiří Fabrik, Ivo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	104798
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/13:43874920
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Francisella; Brucella; Coxiella; Dendritic cells; Infection; Immunology (en)
http://linked.open.../riv/klicoveSlovo	Brucella Coxiella Dendritic cells Infection Francisella Immunology
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5AC3459B6042]
http://linked.open...i/riv/nazevZdroje	Cellular Microbiology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Härtlová, Anetta Stulík, Jiří Fabrik, Ivo Řehulka, Pavel
http://linked.open...ain/vavai/riv/wos	000322885000003
issn	1462-5814
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/cmi.12160
http://localhost/t...ganizacniJednotka	G44

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