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| Description
| - The protective immune response against facultative intracellular bacterial pathogens, as are Brucella melitensis, Francisella tularensis, Listeria monocytogenes, or Salmonella sp. requires concerted action of activated immunocompetent cells. In this respect the dominant role has been attributed to activated T lymphocyte subpopulations and/or activated macrophages. Recently become clear that the B cell subsets are the equivalent partner of T cells during the induction, regulation and expression phases of the immune response against intracellular bacteria. They express their functions by both antibody-dependent and by antibody-independent mechanisms. B cells are able to internalize bacteria through their BCR, extract the antigens from the non-internalizable particles, and are able due to the cross-presentation process activate CD4+ as well as CD8+ T cells. Through the dichotomy of the recognition of bacterial targets by BCR or TLR and by the production of sets of cytokines the B cells regulate the expression of individual branches of acquired immune response. B cells also influence the development of T cell memory. Further, B cells apply their dominant role as the antibody producing cells for influencing the course and final resolution of intracellular bacterial infections. Direct interaction of B cell subpopulations with bacteria results in autonomous B cell differentiation and rapid secretion of bacterium-specific antibodies that influence the pathogen distribution to vital organs. Moreover specific antibodies against intracellular bacteria have been demonstrated to have protective potential. On the other hand the intracellular bacteria survive intracellularly in B cells mainly in non-replicative state and as such constitute the source of systemic infection and/or reservoir for reinfection.
- The protective immune response against facultative intracellular bacterial pathogens, as are Brucella melitensis, Francisella tularensis, Listeria monocytogenes, or Salmonella sp. requires concerted action of activated immunocompetent cells. In this respect the dominant role has been attributed to activated T lymphocyte subpopulations and/or activated macrophages. Recently become clear that the B cell subsets are the equivalent partner of T cells during the induction, regulation and expression phases of the immune response against intracellular bacteria. They express their functions by both antibody-dependent and by antibody-independent mechanisms. B cells are able to internalize bacteria through their BCR, extract the antigens from the non-internalizable particles, and are able due to the cross-presentation process activate CD4+ as well as CD8+ T cells. Through the dichotomy of the recognition of bacterial targets by BCR or TLR and by the production of sets of cytokines the B cells regulate the expression of individual branches of acquired immune response. B cells also influence the development of T cell memory. Further, B cells apply their dominant role as the antibody producing cells for influencing the course and final resolution of intracellular bacterial infections. Direct interaction of B cell subpopulations with bacteria results in autonomous B cell differentiation and rapid secretion of bacterium-specific antibodies that influence the pathogen distribution to vital organs. Moreover specific antibodies against intracellular bacteria have been demonstrated to have protective potential. On the other hand the intracellular bacteria survive intracellularly in B cells mainly in non-replicative state and as such constitute the source of systemic infection and/or reservoir for reinfection. (en)
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| Title
| - The role of B cells in intracellular bacterial pathogen infections
- The role of B cells in intracellular bacterial pathogen infections (en)
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| skos:prefLabel
| - The role of B cells in intracellular bacterial pathogen infections
- The role of B cells in intracellular bacterial pathogen infections (en)
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| skos:notation
| - RIV/60162694:G44__/13:43874904!RIV14-GA0-G44_____
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/13:43874904
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - antigen-presentation; antibodies; cytokines; B lymphocytes; intracellular pathogen (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - B Cells: Molecular Biology, Developmental Origin and Impact on the Immune System
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...v/pocetStranKnihy
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Kročová, Zuzana
- Kubelková, Klára
- Macela, Aleš
- Plzáková, Lenka
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
| - Nova Science Publishers - NY
|
| https://schema.org/isbn
| |
| http://localhost/t...ganizacniJednotka
| |
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