About: Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells

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About: Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We studied effect of valproic acid, a representative of histondeacetylases inhibitors, on cell cycle and protein expression in U-937 PML/RAR cells of human histiocytic lymphoma. Moreover, we tried to potentiate its effect by concomitant treatment with the differentiation agent all-trans retinoic acid. We proved acetylation of nuclear histones H3 and H4 after VA treatment. Activation of non-histone proteins (as p21) preceded this acetylation. Protein p21 as an inhibitor of cyclin dependent kinases causes cell cycle arrest in G1, resulting in a decrease of the percentage of cells in the S phase, as well as in the inhibition of the proliferation, which we demonstrated after VA treatment. Using concomitant treatment with VA and ATRA failed to yield a synergistic or additive effect on p21 expression in our experiments. Thus different treatment schedules should be the aim of further studies. We studied effect of valproic acid, a representative of histondeacetylases inhibitors, on cell cycle and protein expression in U-937 PML/RAR cells of human histiocytic lymphoma. Moreover, we tried to potentiate its effect by concomitant treatment with the differentiation agent all-trans retinoic acid. We proved acetylation of nuclear histones H3 and H4 after VA treatment. Activation of non-histone proteins (as p21) preceded this acetylation. Protein p21 as an inhibitor of cyclin dependent kinases causes cell cycle arrest in G1, resulting in a decrease of the percentage of cells in the S phase, as well as in the inhibition of the proliferation, which we demonstrated after VA treatment. Using concomitant treatment with VA and ATRA failed to yield a synergistic or additive effect on p21 expression in our experiments. Thus different treatment schedules should be the aim of further studies. (en)
Title	Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells (en)
skos:prefLabel	Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells Parallel treatment with valproic acid and all-trans retinoic acid does not potentiate P21 expression in U-937 PML/RAR cells (en)
skos:notation	RIV/60162694:G44__/12:43874776!RIV13-MO0-G44_____
http://linked.open...avai/riv/aktivita	I V
http://linked.open...avai/riv/aktivity	I, V
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vávrová, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	157769
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/12:43874776
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	U-937 cells; protein p21; all-trans retinoic acid; valproic acid (en)
http://linked.open.../riv/klicoveSlovo	valproic acid U-937 cells all-trans retinoic acid protein p21
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[777E836D4B68]
http://linked.open...i/riv/nazevZdroje	Plzeňský lékařský sborník
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	78
http://linked.open...iv/tvurceVysledku	Muthná, Darina Vávrová, Jiřina Řezáčová, Martina Janská, Božena
issn	0551-1038
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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