About: Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents

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About: Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.zsf.jcu.cz/jab/10_1/vavrova10_1.htm
Description	Radiation therapy occupies an important position in the treatment of malignant diseases in spite of the existence of radiation side effects on normal tissues. Thus, substances are being developed which are designed to reduce both the acute and long term radiation effects on healthy tissues. Currently a sulphur-containing compound amifostine (WR2721, ethyol) is used in clinical practice as a radioprotectant. However, it itself has considerable side effects including hypotension (found in 62% of patients), hypocalcaemia, diarrhoea, nausea, and vomiting. Carbon nanospheres, known as fullerenes, and their water soluble derivatives (e.g. C-60(OH)(24), dendrofullerene DF-1) exert anti-oxidative properties and reduce damage to the DNA in irradiated cells. Water soluble fullerenes are low-toxic substances and thus, are attractive in terms of their use as radioprotectants. Radiation therapy occupies an important position in the treatment of malignant diseases in spite of the existence of radiation side effects on normal tissues. Thus, substances are being developed which are designed to reduce both the acute and long term radiation effects on healthy tissues. Currently a sulphur-containing compound amifostine (WR2721, ethyol) is used in clinical practice as a radioprotectant. However, it itself has considerable side effects including hypotension (found in 62% of patients), hypocalcaemia, diarrhoea, nausea, and vomiting. Carbon nanospheres, known as fullerenes, and their water soluble derivatives (e.g. C-60(OH)(24), dendrofullerene DF-1) exert anti-oxidative properties and reduce damage to the DNA in irradiated cells. Water soluble fullerenes are low-toxic substances and thus, are attractive in terms of their use as radioprotectants. (en)
Title	Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents (en)
skos:prefLabel	Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents (en)
skos:notation	RIV/60162694:G44__/12:43874690!RIV13-MO0-G44_____
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OVUOFVZ200806), Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pejchal, Jaroslav Vávrová, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	137356
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/12:43874690
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nanoparticles; radioprotection; antioxidant; fullerenes; ionizing radiation (en)
http://linked.open.../riv/klicoveSlovo	nanoparticles antioxidant radioprotection fullerenes ionizing radiation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[DFD0BF869C5A]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine - print
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Noninvasive measurement of proinflamatory markers of oxidative stress in irradiated as an indicator of received dose of radiation. Protective role of acetyl-L-carnitine
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Pejchal, Jaroslav Vávrová, Jiřina Řezáčová, Martina
http://linked.open...ain/vavai/riv/wos	000300403600001
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	1214-021X
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.2478/v10136-012-0002-2
http://localhost/t...ganizacniJednotka	G44

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