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  • Alpha7 nicotinic acetylcholine receptor (alfa7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of alfa7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer's disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of alfa7 nAChR are suitable for treatment of multiple cognitive dysfunctions such as Alzheimer's disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779 are representative examples of the novel compounds with affinity toward the alfa7 nAChR. Pharmacological, toxicological, and medicinal significance of alfa7 nAChR are discussed throughout this paper.
  • Alpha7 nicotinic acetylcholine receptor (alfa7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of alfa7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer's disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of alfa7 nAChR are suitable for treatment of multiple cognitive dysfunctions such as Alzheimer's disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779 are representative examples of the novel compounds with affinity toward the alfa7 nAChR. Pharmacological, toxicological, and medicinal significance of alfa7 nAChR are discussed throughout this paper. (en)
Title
  • Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology
  • Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology (en)
skos:prefLabel
  • Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology
  • Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology (en)
skos:notation
  • RIV/60162694:G44__/12:43874619!RIV13-MO0-G44_____
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  • RIV/60162694:G44__/12:43874619
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  • antagonist; agonist; cognitive disorder; Alzheimer's disease; schizophrenia; cholinergic anti-inflammatory pathway; inflammation (en)
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  • CH - Švýcarská konfederace
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  • [94D2777EBD3B]
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  • International Journal of Molecular Sciences
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  • 13
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  • Pohanka, Miroslav
http://linked.open...ain/vavai/riv/wos
  • 000300715700060
issn
  • 1661-6596
number of pages
http://bibframe.org/vocab/doi
  • 10.3390/ijms13022219
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  • G44
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