About: Effects of amlodipine on bone metabolism in male albino Wistar rats

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About: Effects of amlodipine on bone metabolism in male albino Wistar rats Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://actavet.vfu.cz/
Description	The aim of our study was to investigate the effect of amlodipine on bone metabolism in male rats. Amlodipine (0.3 mg/100 g BW; gavage) was administered to 8 rats for 8 weeks. Control group (n=8) received aqua pro inj.. Bone marker concentrations of CTX-I and PINP in serum, and BALP in both serum and bone homogenate were measured by ELISA. We investigated expression of BMP-2 in tibia using Western blot, and bone mineral density was measured by DXA in lumbar and caudal vertebrae and in femoral areas. Femurs were used for biomechanical testing. After 8 weeks of amlodipine administration there was decrease in serum levels of BALP (p=0.0009) and CTX-I (p=0.003), and level of BALP in bone homogenate (p=0.026) compared to controls. Expression of BMP-2 was increased after amlodipine administration. Our findings suggest that amlodipine has retarding influence on bone metabolism in rats by decreasing bone turnover, which probably in consequence increases expression of BMP-2. The aim of our study was to investigate the effect of amlodipine on bone metabolism in male rats. Amlodipine (0.3 mg/100 g BW; gavage) was administered to 8 rats for 8 weeks. Control group (n=8) received aqua pro inj.. Bone marker concentrations of CTX-I and PINP in serum, and BALP in both serum and bone homogenate were measured by ELISA. We investigated expression of BMP-2 in tibia using Western blot, and bone mineral density was measured by DXA in lumbar and caudal vertebrae and in femoral areas. Femurs were used for biomechanical testing. After 8 weeks of amlodipine administration there was decrease in serum levels of BALP (p=0.0009) and CTX-I (p=0.003), and level of BALP in bone homogenate (p=0.026) compared to controls. Expression of BMP-2 was increased after amlodipine administration. Our findings suggest that amlodipine has retarding influence on bone metabolism in rats by decreasing bone turnover, which probably in consequence increases expression of BMP-2. (en)
Title	Effects of amlodipine on bone metabolism in male albino Wistar rats Effects of amlodipine on bone metabolism in male albino Wistar rats (en)
skos:prefLabel	Effects of amlodipine on bone metabolism in male albino Wistar rats Effects of amlodipine on bone metabolism in male albino Wistar rats (en)
skos:notation	RIV/60162694:G44__/11:43874773!RIV13-MO0-G44_____
http://linked.open...avai/riv/aktivita	I S V Z
http://linked.open...avai/riv/aktivity	I, S, V, Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Tichý, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	196600
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:43874773
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biomechanical testing; bone mineral density; Western blotting; bone markers (en)
http://linked.open.../riv/klicoveSlovo	bone mineral density Western blotting biomechanical testing bone markers
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[A8178D163D70]
http://linked.open...i/riv/nazevZdroje	Acta Veterinaria Brno
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	80
http://linked.open...iv/tvurceVysledku	Gradošová, Iveta Palička, Vladimír Tichý, Aleš Švejkovská, Klára Živná, Helena Živný, Pavel
http://linked.open...ain/vavai/riv/wos	000301811400012
http://linked.open...n/vavai/riv/zamer	Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	0001-7213
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.2754/avb201180040391
http://localhost/t...ganizacniJednotka	G44

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