About: Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus

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About: Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.3109/13813455.2010.551135
Description	To determine the extent of oxidative stress and DNA damage and repair using a panel of selected markers in patients with type 1 and type 2 diabetes mellitus (T1DM, T2DM), (ii) to find their possible relationships with diabetes compensation and duration, and finally (iii) to test for the effect of functional polymorphisms in the 8-oxoguanin DNA glycosylase (rs1052133), catalase (rs1001179) and superoxide dismutase (rs4880) genes on respective intermediate phenotypes. A total of 207 subjects (23 children and 44 adults with T1DM, 52 adult patients with T2DM and 88 healthy adult control subjects) were enrolled in the study. The following markers of redox state were determined in participants: erythrocyte superoxide dismutase (Ery-SOD), whole blood glutathione peroxidase (WB-GPx), erythrocyte glutathione (Ery-GSH), plasma total antioxidant capacity (P-tAOC) and plasma malondialdehyde (P-MDA). Furthermore, the extent of DNA damage and repair was ascertained using the following parameters: DNA single strand breaks (DNAssb), DNA repair capacity (DNArc) and DNA repair index (DNRI). To determine the extent of oxidative stress and DNA damage and repair using a panel of selected markers in patients with type 1 and type 2 diabetes mellitus (T1DM, T2DM), (ii) to find their possible relationships with diabetes compensation and duration, and finally (iii) to test for the effect of functional polymorphisms in the 8-oxoguanin DNA glycosylase (rs1052133), catalase (rs1001179) and superoxide dismutase (rs4880) genes on respective intermediate phenotypes. A total of 207 subjects (23 children and 44 adults with T1DM, 52 adult patients with T2DM and 88 healthy adult control subjects) were enrolled in the study. The following markers of redox state were determined in participants: erythrocyte superoxide dismutase (Ery-SOD), whole blood glutathione peroxidase (WB-GPx), erythrocyte glutathione (Ery-GSH), plasma total antioxidant capacity (P-tAOC) and plasma malondialdehyde (P-MDA). Furthermore, the extent of DNA damage and repair was ascertained using the following parameters: DNA single strand breaks (DNAssb), DNA repair capacity (DNArc) and DNA repair index (DNRI). (en)
Title	Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus (en)
skos:prefLabel	Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus (en)
skos:notation	RIV/60162694:G44__/11:00002596!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	I V Z
http://linked.open...avai/riv/aktivity	I, V, Z(MSM0021620814)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Štětina, Rudolf
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	219542
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002596
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Diabetes melitus; oxidative stress; DNA damage (en)
http://linked.open.../riv/klicoveSlovo	Diabetes melitus DNA damage oxidative stress
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A7F45143C0C1]
http://linked.open...i/riv/nazevZdroje	Archives of Physiology and Biochemistry
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	117
http://linked.open...iv/tvurceVysledku	Pomahačová, Renata Štětina, Rudolf Rušavý, Zdeněk Racek, Jaroslav Kaňková, Kateřina Varvařovská, Jana Lacigová, Silva Pácal, Lukáš Tanhäuserová, Veronika
http://linked.open...n/vavai/riv/zamer	Prevention, diagnostics and therapy of diabetes mellitus, metabolic and endocrine damage of organism
issn	1381-3455
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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