About: Proteomic insights into chronic anthracycline cardiotoxicity

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.yjmcc.2011.01.018
Description	In this study global molecular changes associated with chronic anthracycline cardiotoxicity were analyzed for the first time using proteomic techniques. This approach identified 47 proteins significantly changed due to the treatment. Important changes were found in mitochondrial oxidative phosphorylation and energy channeling, intermediate filament desmin, myosin light chains, proteolytic systems, chaperon proteins and many others. Furthermore, basement membrane and extracellular matrix remodeling was documented. The above described changes were corroborated with other molecular and biochemical methods. Hence, in this study the proteomic signature of chronic anthracycline cardiotoxicity was described and it enhances understanding to the molecular basis of this iatrogenic disease. In this study global molecular changes associated with chronic anthracycline cardiotoxicity were analyzed for the first time using proteomic techniques. This approach identified 47 proteins significantly changed due to the treatment. Important changes were found in mitochondrial oxidative phosphorylation and energy channeling, intermediate filament desmin, myosin light chains, proteolytic systems, chaperon proteins and many others. Furthermore, basement membrane and extracellular matrix remodeling was documented. The above described changes were corroborated with other molecular and biochemical methods. Hence, in this study the proteomic signature of chronic anthracycline cardiotoxicity was described and it enhances understanding to the molecular basis of this iatrogenic disease. (en)
Title	Proteomic insights into chronic anthracycline cardiotoxicity Proteomic insights into chronic anthracycline cardiotoxicity (en)
skos:prefLabel	Proteomic insights into chronic anthracycline cardiotoxicity Proteomic insights into chronic anthracycline cardiotoxicity (en)
skos:notation	RIV/60162694:G44__/11:00002570!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GA305/09/0416), V, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lenčo, Juraj Stulík, Jiří Fučíková, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	224828
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002570
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chronic anthracycline cardiotoxicity; proteomics; desmin; complex I; energy channeling; superoxide dismutase (en)
http://linked.open.../riv/klicoveSlovo	proteomics superoxide dismutase chronic anthracycline cardiotoxicity complex I desmin energy channeling
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[6CA5141FDFA3]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular and Cellular Cardiology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Myocardial damage induced by anticancer drugs and ischemia-reperfusion: new possibilities of pharmacological cardioprotection.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Adamcová, Michaela Lenčo, Juraj Mičuda, Stanislav Stulík, Jiří Šimůnek, Tomáš Geršl, Vladimír Jirkovský, Eduard Popelová, Olga Štěrba, Martin Mazurová, Yvona Fučíková, Alena Doleželová, Eva
http://linked.open...ain/vavai/riv/wos	000289748200012
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0022-2828
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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