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| Description
| - We studied the relationship between DNA damage, DNA repair rates and mRNA expression levels of DNA repair genes XRCC1, hOGG1 and XPC in a group of 71 styrene-exposed workers and 51 control individuals. The exposure was assessed by measuring the concentration of styrene in ambient air and in blood. Parameters of DNA damage (measured as single-strand breaks) and DNA repair rates were analyzed in peripheral blood lymphocytes in both groups. A significantly negative correlation was recorded between the DNA damage and styrene concentration at the workplace (r=-0.38, p=0.0001, Pearson). The DNA repair rates were two-fold higher in the exposed group than in the controls (p=0.027; Mann-Whitney U-test). Using the pooled data (the present study and that published by us previously, comprising 113 exposed and 61 control individuals), the DNA repair rates were consistently significantly higher in the exposed group as compared to controls (p=0.0001; Mann-Whitney U-test). mRNA expression levels of XRCC1, hOGG1 and XPC genes were lower in the exposed groups as compared to the controls (p<0.0001; Mann-Whitney U-test). Expression levels of XRCC1, hOGG1 and XPC genes significantly correlated with styrene concentration in blood, a marker of internal exposure (r=-0.66, r=-0.36, and r=-0.40, p=0.0001, respectively; Pearson).Present results provide the evidence on the inverse relationship between DNA damage and DNA repair rates, with further indications of possible DNA repair induction in styrene-exposed subjects. We did not observe any induction of gene expression in the studied DNA repair genes.
- We studied the relationship between DNA damage, DNA repair rates and mRNA expression levels of DNA repair genes XRCC1, hOGG1 and XPC in a group of 71 styrene-exposed workers and 51 control individuals. The exposure was assessed by measuring the concentration of styrene in ambient air and in blood. Parameters of DNA damage (measured as single-strand breaks) and DNA repair rates were analyzed in peripheral blood lymphocytes in both groups. A significantly negative correlation was recorded between the DNA damage and styrene concentration at the workplace (r=-0.38, p=0.0001, Pearson). The DNA repair rates were two-fold higher in the exposed group than in the controls (p=0.027; Mann-Whitney U-test). Using the pooled data (the present study and that published by us previously, comprising 113 exposed and 61 control individuals), the DNA repair rates were consistently significantly higher in the exposed group as compared to controls (p=0.0001; Mann-Whitney U-test). mRNA expression levels of XRCC1, hOGG1 and XPC genes were lower in the exposed groups as compared to the controls (p<0.0001; Mann-Whitney U-test). Expression levels of XRCC1, hOGG1 and XPC genes significantly correlated with styrene concentration in blood, a marker of internal exposure (r=-0.66, r=-0.36, and r=-0.40, p=0.0001, respectively; Pearson).Present results provide the evidence on the inverse relationship between DNA damage and DNA repair rates, with further indications of possible DNA repair induction in styrene-exposed subjects. We did not observe any induction of gene expression in the studied DNA repair genes. (en)
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| Title
| - DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes
- DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (en)
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| skos:prefLabel
| - DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes
- DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (en)
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| skos:notation
| - RIV/60162694:G44__/11:00002563!RIV12-MO0-G44_____
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - I, P(GA310/07/1430), P(IAA500390806), V, Z(AV0Z50390512)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/11:00002563
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - styrene exposure; genotoxicity; DNA repair; DNA repair rates; gene expression styrene exposure, genotoxicity, DNA repair, DNA repair rates, gene expression, styrene exposure, genotoxicity, DNA repair, DNA repair rates, gene expression, styrene exposure, genotoxicity, DNA repair, DNA repair rates, gene expression, (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Lipská, Ludmila
- Naccarati, Alessio
- Vodička, Pavel
- Vodičková, Ludmila
- Šmerhovský, Zdeněk
- Štětina, Rudolf
- Hanová, Monika
- Hemminki, Kari
- Hlaváč, Pavel
- Kumar, Rajiv
- Polaková, Veronika
- Slyšková, Jana
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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