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Description
  • Cellular senescence is a condition of long-lasting proliferation arrest, induced in cells in response to various stressors. These stressors include telomere shortening and/or dysfunction, DNA damage, and oncogene signalling. Epithelial and mesenchymal cells and also tumour cells derived from these tissues are more resistant to radiation-induced apoptosis and respond to irradiation mainly by senescence. Senescence-associated molecular mechanisms related to the activation of canonical DNA damage pathway ATM-p53 as well as mechanisms related to the extracellular signals, cytokine increase and up-regulation of their receptors are discussed in this review.
  • Cellular senescence is a condition of long-lasting proliferation arrest, induced in cells in response to various stressors. These stressors include telomere shortening and/or dysfunction, DNA damage, and oncogene signalling. Epithelial and mesenchymal cells and also tumour cells derived from these tissues are more resistant to radiation-induced apoptosis and respond to irradiation mainly by senescence. Senescence-associated molecular mechanisms related to the activation of canonical DNA damage pathway ATM-p53 as well as mechanisms related to the extracellular signals, cytokine increase and up-regulation of their receptors are discussed in this review. (en)
Title
  • The importance of senescence in ionizing radiation-induced tumour suppression
  • The importance of senescence in ionizing radiation-induced tumour suppression (en)
skos:prefLabel
  • The importance of senescence in ionizing radiation-induced tumour suppression
  • The importance of senescence in ionizing radiation-induced tumour suppression (en)
skos:notation
  • RIV/60162694:G44__/11:00002535!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MO0FVZ0000501), Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 203890
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/11:00002535
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • review; senescence; ionizing radiation; cytokine expression (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [6481DD48C29B]
http://linked.open...i/riv/nazevZdroje
  • Folia biologica (Prague)
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 57
http://linked.open...iv/tvurceVysledku
  • Vávrová, Jiřina
  • Řezáčová, Martina
http://linked.open...ain/vavai/riv/wos
  • 000290506000001
http://linked.open...n/vavai/riv/zamer
issn
  • 0015-5500
number of pages
http://localhost/t...ganizacniJednotka
  • G44
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