About: Phosphorylation of histone H2AX in peripheral blood mononuclear cells after thoracic irradiation of rats

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About: Phosphorylation of histone H2AX in peripheral blood mononuclear cells after thoracic irradiation of rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.2478/v10136-011-0007-2
Description	Lymphocytes are the most radiosensitive cells. After exposure IR die by apoptosis at a rate proportional to the dose received. We demonstrated that one hour after whole-body irradiation of rats, histone H2AX in the lymphocyte nuclei was quickly phosphorylated on serine 139. In the work presented here, we studied the kinetics of lymphocyte depletion in the blood and phosphorylation of histone H2AX in the peripheral blood lymphocytes after local (thoracic) irradiation of rats. Twenty-four hours after whole-body irradiation of the rats at a dose of 5 Gy, the lymphocyte count declined to almost zero values, whereas after local irradiation of the thorax area, the counts of lymphocytes in the peripheral blood remained unaltered. We employed flow-cytometric and microscopic gammaH2AX determination 1 h after thoracic irradiation of rats. We revealed a dose dependence on the increase in gammaH2AX in a dose range of 10-30 Gy. The microscopic method was more sensitive in the case of lower radiation doses. Lymphocytes are the most radiosensitive cells. After exposure IR die by apoptosis at a rate proportional to the dose received. We demonstrated that one hour after whole-body irradiation of rats, histone H2AX in the lymphocyte nuclei was quickly phosphorylated on serine 139. In the work presented here, we studied the kinetics of lymphocyte depletion in the blood and phosphorylation of histone H2AX in the peripheral blood lymphocytes after local (thoracic) irradiation of rats. Twenty-four hours after whole-body irradiation of the rats at a dose of 5 Gy, the lymphocyte count declined to almost zero values, whereas after local irradiation of the thorax area, the counts of lymphocytes in the peripheral blood remained unaltered. We employed flow-cytometric and microscopic gammaH2AX determination 1 h after thoracic irradiation of rats. We revealed a dose dependence on the increase in gammaH2AX in a dose range of 10-30 Gy. The microscopic method was more sensitive in the case of lower radiation doses. (en)
Title	Phosphorylation of histone H2AX in peripheral blood mononuclear cells after thoracic irradiation of rats Phosphorylation of histone H2AX in peripheral blood mononuclear cells after thoracic irradiation of rats (en)
skos:prefLabel	Phosphorylation of histone H2AX in peripheral blood mononuclear cells after thoracic irradiation of rats Phosphorylation of histone H2AX in peripheral blood mononuclear cells after thoracic irradiation of rats (en)
skos:notation	RIV/60162694:G44__/11:00002534!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OVUOFVZ200806), Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pejchal, Jaroslav Zárybnická, Lenka Šinkorová, Zuzana Vávrová, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	220216
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002534
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	gammaH2AX; biodosimetry; ionizing radiation; thoracic; lymphocytes (en)
http://linked.open.../riv/klicoveSlovo	lymphocytes biodosimetry gammaH2AX thoracic ionizing radiation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[608090F4DACB]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine - print
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Noninvasive measurement of proinflamatory markers of oxidative stress in irradiated as an indicator of received dose of radiation. Protective role of acetyl-L-carnitine
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Havelek, Radim Pejchal, Jaroslav Vávrová, Jiřina Zárybnická, Lenka Řezáčová, Martina Šinkorová, Zuzana
http://linked.open...ain/vavai/riv/wos	000295970900004
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	1214-021X
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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