About: Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections

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About: Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.2478/v10136-009-0033-5
Description	The aim of this experimental in vivo study was to examine the effect of topically-used gentamicin bound to microdispersed oxidized cellulose (MDOC) in nanofibre form in the treatment of deep surgical site infections and to compare it with Garamycin SchwammR. Twelve domestic swine were used in a model of a full-thickness infected dermal wound. The effectiveness of both forms of gentamicin were tedted in wound infections caused by Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effectiveness of gentamicin-MDOC and Garamycin SchwammR were comparable according to microbiological culture findings, with no statistically significant differences. When macroscopically assessed, 100% of the infected wounds treated by gentamicin-MDOC were without signs of infection, compared with only 16.7% when Garamycin SchwammR was used and this was of statistical significance. Therefore when combined with a nanofibre MDOC carrier, topically-used gentamicin is rendered more effective for the treatment of full-thickness skin infections. The aim of this experimental in vivo study was to examine the effect of topically-used gentamicin bound to microdispersed oxidized cellulose (MDOC) in nanofibre form in the treatment of deep surgical site infections and to compare it with Garamycin SchwammR. Twelve domestic swine were used in a model of a full-thickness infected dermal wound. The effectiveness of both forms of gentamicin were tedted in wound infections caused by Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effectiveness of gentamicin-MDOC and Garamycin SchwammR were comparable according to microbiological culture findings, with no statistically significant differences. When macroscopically assessed, 100% of the infected wounds treated by gentamicin-MDOC were without signs of infection, compared with only 16.7% when Garamycin SchwammR was used and this was of statistical significance. Therefore when combined with a nanofibre MDOC carrier, topically-used gentamicin is rendered more effective for the treatment of full-thickness skin infections. (en)
Title	Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections (en)
skos:prefLabel	Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections (en)
skos:notation	RIV/60162694:G44__/11:00002525!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MO0FVZ0000503)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lochman, Petr Páral, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	201059
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002525
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	gentamicin; microdispersed oxidized cellulose; surgical site infections; Garamycin Schwamm (en)
http://linked.open.../riv/klicoveSlovo	Garamycin Schwamm gentamicin microdispersed oxidized cellulose surgical site infections
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[66F86CD9071E]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine - print
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Kočí, Jaromír Lochman, Petr Páral, Jiří
http://linked.open...ain/vavai/riv/wos	000291678000003
http://linked.open...n/vavai/riv/zamer	Military - medical aspects of war surgery and war internal medicine
issn	1214-021X
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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