About: Suture-free anastomosis of the colon: experimental comparison of two cyanoacrylate adhesives     Goto   Sponge   NotDistinct   Permalink

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Description
  • We explored the potential of two cyanoacrylate tissue adhesives for constructing colonic anastomoses. The study involved 12 female domestic pigs. The animals were divided into two equal groups. In both groups, the sigmoid colon was transected. An intestinal anastomosis was constructed with a modified circular stapler (all staples were withdrawn) and cyanoacrylate tissue adhesives. Glubran 2R was used in group A and DermabondR was applied in group B. Fourteen days after the first operation, a follow-up surgery was performed in both groups. The glued section of the colon was resected, processed with the standard paraffin technique and stained with haematoxylin-eosin. The finished specimens were examined under light microscopy. Assessments were made for the presence of fibroblasts, neutrophils, giant polynuclear cells, neovascularisation and collagen deposits. Adhesions, anastomotic dehiscence, peri-anastomotic inflammation and intestinal healing were assessed peri-operatively.All anastomoses in group A healed with no signs of pathology. In group B, fibrotic adhesions and stenoses tended to occur in areas surrounding the anastomoses. Histological examinations confirmed increased fibrosis.The tissue adhesive Glubran 2 appears to be (under experimental conditions) a promising synthetic adhesive for colonic anastomosis construction; conversely, the tissue adhesive Dermabond was unsuitable for suture-free anastomosis constroction.
  • We explored the potential of two cyanoacrylate tissue adhesives for constructing colonic anastomoses. The study involved 12 female domestic pigs. The animals were divided into two equal groups. In both groups, the sigmoid colon was transected. An intestinal anastomosis was constructed with a modified circular stapler (all staples were withdrawn) and cyanoacrylate tissue adhesives. Glubran 2R was used in group A and DermabondR was applied in group B. Fourteen days after the first operation, a follow-up surgery was performed in both groups. The glued section of the colon was resected, processed with the standard paraffin technique and stained with haematoxylin-eosin. The finished specimens were examined under light microscopy. Assessments were made for the presence of fibroblasts, neutrophils, giant polynuclear cells, neovascularisation and collagen deposits. Adhesions, anastomotic dehiscence, peri-anastomotic inflammation and intestinal healing were assessed peri-operatively.All anastomoses in group A healed with no signs of pathology. In group B, fibrotic adhesions and stenoses tended to occur in areas surrounding the anastomoses. Histological examinations confirmed increased fibrosis.The tissue adhesive Glubran 2 appears to be (under experimental conditions) a promising synthetic adhesive for colonic anastomosis construction; conversely, the tissue adhesive Dermabond was unsuitable for suture-free anastomosis constroction. (en)
Title
  • Suture-free anastomosis of the colon: experimental comparison of two cyanoacrylate adhesives
  • Suture-free anastomosis of the colon: experimental comparison of two cyanoacrylate adhesives (en)
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  • Suture-free anastomosis of the colon: experimental comparison of two cyanoacrylate adhesives
  • Suture-free anastomosis of the colon: experimental comparison of two cyanoacrylate adhesives (en)
skos:notation
  • RIV/60162694:G44__/11:00002524!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(OVUOFVZ200804), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 233577
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/11:00002524
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • colon; anastomosis; suture-free; cyanoacrylate; adhesive (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [60A3B6D34CF4]
http://linked.open...i/riv/nazevZdroje
  • Journal of Gastrointestinal Surgery
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 15
http://linked.open...iv/tvurceVysledku
  • Klein, Leo
  • Lochman, Petr
  • Šubrt, Zdeněk
  • Páral, Jiří
  • Turek, Zdeněk
  • Hadži Nikolov, Dimitar
  • Vejběra, Martin
http://linked.open...ain/vavai/riv/wos
  • 000288762700012
http://linked.open...n/vavai/riv/zamer
issn
  • 1091-255X
number of pages
http://localhost/t...ganizacniJednotka
  • G44
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