About: Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model

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About: Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model Goto Sponge NotDistinct Permalink

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rdfs:seeAlso	http://www.bmj.sk/2011/11210-01.pdf
Description	The present experiment is based on biochemical assessment of nerve agent soman intoxication and atropine, respectively atropine and HI-6, trimedoxime or K203 treatment in rats. Background: Nerve agents are toxic substances irreversibly inhibiting enzyme acetylcholinesterase (AChE). Treatment is typically based on application of atropine and oxime reactivator. Atropine is able to protect overstimulation of muscarinic acetylcholine receptors. Application of oxime reactivator enable return of AChE activity and full suppression of intoxication. The most striking shifts were found for blood acetylcholinesterase and plasma creatinine, glucose, inorganic phosphate as well as uric acid. Lactate dehydrogenase and aspartate aminotransferase assays were useless due to soman interference. Conclusion: It was demonstrated that treatment was able to protect poisoned animals from metabolic disorder represented by hyperglycemia and nephropathy represented by hyperuricemia and elevated creatinine. Soman exposure and treatment with the oxime reactivators and/or atropine contains quite complex and still not well understood side mechanisms (Tab. 2, Fig. 1, Ref. 25). The present experiment is based on biochemical assessment of nerve agent soman intoxication and atropine, respectively atropine and HI-6, trimedoxime or K203 treatment in rats. Background: Nerve agents are toxic substances irreversibly inhibiting enzyme acetylcholinesterase (AChE). Treatment is typically based on application of atropine and oxime reactivator. Atropine is able to protect overstimulation of muscarinic acetylcholine receptors. Application of oxime reactivator enable return of AChE activity and full suppression of intoxication. The most striking shifts were found for blood acetylcholinesterase and plasma creatinine, glucose, inorganic phosphate as well as uric acid. Lactate dehydrogenase and aspartate aminotransferase assays were useless due to soman interference. Conclusion: It was demonstrated that treatment was able to protect poisoned animals from metabolic disorder represented by hyperglycemia and nephropathy represented by hyperuricemia and elevated creatinine. Soman exposure and treatment with the oxime reactivators and/or atropine contains quite complex and still not well understood side mechanisms (Tab. 2, Fig. 1, Ref. 25). (en)
Title	Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model (en)
skos:prefLabel	Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model (en)
skos:notation	RIV/60162694:G44__/11:00002467!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501), Z(MSM6215712402)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kassa, Jiří Kuča, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	188249
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002467
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nerve agents; sarin; oxime reactivator; acetylcholinesterase; acetylcholine; cholinergic crisis (en)
http://linked.open.../riv/klicoveSlovo	oxime reactivator nerve agents acetylcholinesterase sarin acetylcholine cholinergic crisis
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[E9DE67BF8A80]
http://linked.open...i/riv/nazevZdroje	Bratislava Medical Journal-Bratislavske Lekarske Listy
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	112
http://linked.open...iv/tvurceVysledku	Kassa, Jiří Kuča, Kamil Pikula, Jiří Pohanka, Miroslav
http://linked.open...ain/vavai/riv/wos	000294514400001
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN Veterinary aspects of food safety and quality
issn	0006-9248
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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