About: Current study on the development of bis-pyridinium oxime reactivators for the antidotal treatment of poisoning by toxic organophosphorus agents

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About: Current study on the development of bis-pyridinium oxime reactivators for the antidotal treatment of poisoning by toxic organophosphorus agents Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.2174/138527211794072579
Description	A number of oxime reactivators have been synthesized and studied for the antidotal treatment of poisoning by toxic organophosphorus agents, and several oximes are currently available to reactivate the organophosphorus agents-induced acetylcholinesterase inhibition. However, there is no oxime with broad spectrum suitable for the antidotal treatment of poisoning with various organoposphorus warfare agents as well as insecticides. In addition, current available oximes have very limited brain-blood barrier (BBB) penetration, even though hydrophobic toxic organophosphorus agents can easily penetrate BBB. A number of oxime reactivators have been synthesized and studied for the antidotal treatment of poisoning by toxic organophosphorus agents, and several oximes are currently available to reactivate the organophosphorus agents-induced acetylcholinesterase inhibition. However, there is no oxime with broad spectrum suitable for the antidotal treatment of poisoning with various organoposphorus warfare agents as well as insecticides. In addition, current available oximes have very limited brain-blood barrier (BBB) penetration, even though hydrophobic toxic organophosphorus agents can easily penetrate BBB. (en)
Title	Current study on the development of bis-pyridinium oxime reactivators for the antidotal treatment of poisoning by toxic organophosphorus agents Current study on the development of bis-pyridinium oxime reactivators for the antidotal treatment of poisoning by toxic organophosphorus agents (en)
skos:prefLabel	Current study on the development of bis-pyridinium oxime reactivators for the antidotal treatment of poisoning by toxic organophosphorus agents Current study on the development of bis-pyridinium oxime reactivators for the antidotal treatment of poisoning by toxic organophosphorus agents (en)
skos:notation	RIV/60162694:G44__/11:00002447!RIV12-MSM-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ME09086)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	192503
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002447
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Acetylcholinesterase; oxim reactivator; bis-pyridinium oximes; nerve agents; pesticide; blood-brain barrier (en)
http://linked.open.../riv/klicoveSlovo	Acetylcholinesterase bis-pyridinium oximes blood-brain barrier nerve agents oxim reactivator pesticide
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[B75ECAFF9868]
http://linked.open...i/riv/nazevZdroje	Current Organic Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of novel antidotal treatment against organophosphorus pesticides
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Jung, Young-Sik Kuča, Kamil
http://linked.open...ain/vavai/riv/wos	000287303000005
issn	1385-2728
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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