About: Application of proteomics in biomarker discovery: a primer for the clinician

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ever since proteomics was proven to be capable of characterizing a large number of differences in both protein quality and quantity, it has been applied in various areas of biomedicine, ranging from the deciphering molecular pathogenesis of diseases to the characterization of novel drug targets and the discovery of potential diagnostic biomarkers. Indeed, the biomarker discovery in human plasma is clearly one of the areas with enormous potential. However, without proper planning and implementation of specific techniques, the efforts and expectations may very easily be hampered. Numerous earlier projects aimed at clinical proteomics, characterized by exaggerated enthusiasm, often underestimated some principal obstacles of plasma biomarker discovery. Consequently, ambiguous and insignificant results soon led to a more critical view in this field. In this article, we critically review the current state of proteomic approaches for biomarker discovery and validation, in order to provide basi Ever since proteomics was proven to be capable of characterizing a large number of differences in both protein quality and quantity, it has been applied in various areas of biomedicine, ranging from the deciphering molecular pathogenesis of diseases to the characterization of novel drug targets and the discovery of potential diagnostic biomarkers. Indeed, the biomarker discovery in human plasma is clearly one of the areas with enormous potential. However, without proper planning and implementation of specific techniques, the efforts and expectations may very easily be hampered. Numerous earlier projects aimed at clinical proteomics, characterized by exaggerated enthusiasm, often underestimated some principal obstacles of plasma biomarker discovery. Consequently, ambiguous and insignificant results soon led to a more critical view in this field. In this article, we critically review the current state of proteomic approaches for biomarker discovery and validation, in order to provide basi (en)
Title	Application of proteomics in biomarker discovery: a primer for the clinician Application of proteomics in biomarker discovery: a primer for the clinician (en)
skos:prefLabel	Application of proteomics in biomarker discovery: a primer for the clinician Application of proteomics in biomarker discovery: a primer for the clinician (en)
skos:notation	RIV/60162694:G44__/10:00002417!RIV11-MZ0-G44_____
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(NR9253), S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Lenčo, Juraj Tambor, Vojtěch Stulík, Jiří Fučíková, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	247478
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002417
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Proteomics * Biomarker * Plasma * Mass spectrometry (en)
http://linked.open.../riv/klicoveSlovo	Proteomics * Biomarker * Plasma * Mass spectrometry
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[6CF357553D2D]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Protein biomarkers in hypertrophic cardiomyopathy
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Kacerovský, Marian Lenčo, Juraj Pudil, Radek Stulík, Jiří Tambor, Vojtěch Řeháček, Vít Fučíková, Alena
http://linked.open...ain/vavai/riv/wos	000282054700002
issn	0862-8408
number of pages	27 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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