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rdf:type
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Description
| - In this work we aim to summarize the universality of this compound, its reactivatiom potency when different cholinesterase inhibitors are used. Background: Pralidoxime is considered as a gold standard of acetylcholinesterase reactivators - antidotes used in case of nerve agent poisonings. It is commercially available worldwide since many years back. However, several studies describe this oxime as an old-fashion antidote Methods: Pralidoxime was synthesized at our department. The reactivating efficacy was tested on 10% (w/v) rat brain homogenate that was incubated with appropriate inhibitor for 30 minutes to reach 96% inhibition of AChE. Then, pralidoxime was added for 10 minutes. Measurements were performed at 25 °C, pH 8, and at the concentrations of the AChE reactivators at 10-3 and 10-5 M. The activities of brain AChE were measured by a potentiostatic method. Results: No sufficient reactivation was achieved at the concentration 10-5 M, which is a concentration that is possible to reach after adm
- In this work we aim to summarize the universality of this compound, its reactivatiom potency when different cholinesterase inhibitors are used. Background: Pralidoxime is considered as a gold standard of acetylcholinesterase reactivators - antidotes used in case of nerve agent poisonings. It is commercially available worldwide since many years back. However, several studies describe this oxime as an old-fashion antidote Methods: Pralidoxime was synthesized at our department. The reactivating efficacy was tested on 10% (w/v) rat brain homogenate that was incubated with appropriate inhibitor for 30 minutes to reach 96% inhibition of AChE. Then, pralidoxime was added for 10 minutes. Measurements were performed at 25 °C, pH 8, and at the concentrations of the AChE reactivators at 10-3 and 10-5 M. The activities of brain AChE were measured by a potentiostatic method. Results: No sufficient reactivation was achieved at the concentration 10-5 M, which is a concentration that is possible to reach after adm (en)
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Title
| - Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro
- Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro (en)
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skos:prefLabel
| - Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro
- Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro (en)
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skos:notation
| - RIV/60162694:G44__/10:00002398!RIV11-MSM-G44_____
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/10:00002398
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cholinesterase; reactivator; oxime; inhibitor; pralidoxime (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Bratislava Medical Journal-Bratislavske Lekarske Listy
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Hrabinová, Martina
- Kuča, Kamil
- Pohanka, Miroslav
- Žďárová Karasová, Jana
- Soukup, Ondřej
- Tobin, G.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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